Asada Rikako, Mizuno Satoshi, Yu Yoshihiko, Hamamoto Yuji, Anazawa Tetsuya, Ito Daisuke, Kitagawa Masato, Hasegawa Daisuke
Laboratory of Veterinary Radiology, Nippon Veterinary and Life Science University, Musashino 180-8602, Japan.
Veterinary Medical Teaching Hospital, Nippon Veterinary and Life Science University, Musashino 180-8602, Japan.
Brain Sci. 2021 Nov 4;11(11):1462. doi: 10.3390/brainsci11111462.
Corpus callosotomy (CC) is an established palliative surgery for human patients with drug-resistant epilepsy (DRE), especially those with generalized seizures and multiple or unknown epileptogenic focus. However, there are no reports to describe CC in canine patients with epilepsy. Three client-owned Cavalier King Charles Spaniels with DRE are included in this case series. In presurgical evaluations, an apparent epileptogenic zone was not detected in each dog and CC was conducted. Total CC was performed in one dog, whereas the other two received partial CC. One dog recovered from surgery without any complications, but died suddenly by an unknown cause at 10 h after surgery. For the other two dogs, postoperative evaluations including seizure outcomes, complications, and quality of life of the dogs and owners were assessed for at least 12 months. Both dogs showed a remarkable decrease in seizure frequency (averaged 80.3% reduction) and severity after surgery. The antiseizure medications were maintained, and not only the mentation and activity of the dogs, but also the quality of life of dogs and owners were improved postoperatively. Although technical improvement and more large-scale studies are needed, CC is a treatment option for dogs with DRE in veterinary medicine.
胼胝体切开术（CC）是一种针对耐药性癫痫（DRE）人类患者的既定姑息性手术，尤其是那些患有全身性癫痫发作且有多个或不明癫痫病灶的患者。然而，尚无关于癫痫犬患者CC手术的报道。本病例系列纳入了3只患有DRE的客户拥有的骑士查理王小猎犬。在术前评估中，每只犬均未检测到明显的癫痫病灶区，遂进行了CC手术。1只犬进行了完全胼胝体切开术，而另外2只接受了部分胼胝体切开术。1只犬术后恢复良好，无任何并发症，但在术后10小时突然不明原因死亡。对于另外2只犬，对其术后评估包括癫痫发作结果、并发症以及犬和主人的生活质量，评估时间至少为12个月。两只犬术后癫痫发作频率均显著降低（平均降低80.3%），发作严重程度也有所减轻。抗癫痫药物维持使用，术后不仅犬的精神状态和活动能力得到改善，犬及其主人的生活质量也得到了提高。尽管需要技术改进和更多大规模研究，但CC在兽医学中是治疗患有DRE犬的一种选择。
