Department of Bio-informatics, School of Computer and Information Sciences, Galgotias University, Greater noida, India.
Front Biosci (Landmark Ed). 2013 Jun 1;18(3):1030-50. doi: 10.2741/4161.
Pharmaceuticals in conjunction with nanoparticle delivery systems are growing towards new heights. The aim of this review is to gain a thorough understanding of different types and characteristics of nanoparticle based delivery systems, important properties of delivery systems, pharmaceutical ingredient loading and release in the nanoparticle delivery systems. In this review, we have also highlighted about the promising pharmaceutical deliveries like brain targeted delivery, ocular delivery, oral delivery, dermal and transdermal delivery, cancer chemotherapy, vaccine delivery, nucleic acids delivery and delivery system coupling to implants. A snapshot of the nanoparticle mediated drug deliveries which are commercially available and ongoing clinical trials have been provided.
药物与纳米颗粒传递系统相结合正在朝着新的高度发展。本综述的目的是深入了解不同类型和特点的基于纳米颗粒的传递系统、传递系统的重要性质、药物成分在纳米颗粒传递系统中的负载和释放。在本综述中,我们还强调了有前途的药物传递系统,如脑靶向传递、眼部传递、口服传递、皮肤和经皮传递、癌症化疗、疫苗传递、核酸传递以及与植入物相结合的传递系统。提供了纳米颗粒介导的药物传递系统的商业应用和正在进行的临床试验的快照。