用于治疗目的蛋白质和基因的下一代递送系统：为何以及如何？
Next generation delivery system for proteins and genes of therapeutic purpose: why and how?
作者信息
Sharma Ashish Ranjan, Kundu Shyamal Kumar, Nam Ju-Suk, Sharma Garima, Priya Doss C George, Lee Sang-Soo, Chakraborty Chiranjib
机构信息
Institute for Skeletal Aging & Orthopedic Surgery, Hallym University Chuncheon Sacred Heart Hospital, Chuncheon 200704, Republic of Korea.
Department of Physics, School of Basic and Applied Sciences, Galgotias University, Greater Noida 203201, India.
出版信息
Biomed Res Int. 2014;2014:327950. doi: 10.1155/2014/327950. Epub 2014 Jul 15.
Proteins and genes of therapeutic interests in conjunction with different delivery systems are growing towards new heights. "Next generation delivery systems" may provide more efficient platform for delivery of proteins and genes. In the present review, snapshots about the benefits of proteins or gene therapy, general procedures for therapeutic protein or gene delivery system, and different next generation delivery system such as liposome, PEGylation, HESylation, and nanoparticle based delivery have been depicted with their detailed explanation.
与不同递送系统相结合的具有治疗意义的蛋白质和基因正迈向新高度。“下一代递送系统”可能为蛋白质和基因的递送提供更高效的平台。在本综述中，已描述了蛋白质或基因治疗的益处、治疗性蛋白质或基因递送系统的一般程序，以及不同的下一代递送系统，如脂质体、聚乙二醇化、羟乙基淀粉化和基于纳米颗粒的递送，并对其进行了详细解释。
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