Department of Obstetrics and Gynecology, the Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Front Biosci (Landmark Ed). 2013 Jun 1;18(4):1373-83. doi: 10.2741/4186.
Outcome of a pregnancy is dependent on high-quality ovulation, successful fertilization, normal embryonic and fetal development, and homeostasis of amniotic fluid. Throughout pregnancy, aquaporins are expressed in the placenta, uterus, adnexa, brain, urinary system, and the lacrimal gland. The regional and temporal regulation of aquaporins play important roles in normal pregnancy, fetal growth, and homeostasis of amniotic fluid volume, and water handling in other organs. The pregnant phenotypes of aquaporin-knockout mice provide direct evidence that aquaporins deficiency results in adverse outcome of pregnancy. Therefore, screening for modulation of aquaporin in abnormal pregnancy becomes desirable. Alteration of aquaporins is seen in preeclampsia, abnormal amniotic fluid volume, chorioamnionitis, and maternal under-nourished pregnancy. Although the functional importance of aquaporins remains to be elucidated, its expression and regulation in abnormal pregnancy suggests potential therapeutic strategies for the treatment of abnormal pregnancy.
妊娠结局取决于高质量的排卵、受精成功、胚胎和胎儿的正常发育以及羊水的内环境稳定。在整个妊娠期间，水通道蛋白在胎盘、子宫、附件、大脑、泌尿系统和泪腺中表达。水通道蛋白的区域和时间调节在正常妊娠、胎儿生长和羊水体积内环境稳定以及其他器官的水代谢中发挥重要作用。水通道蛋白敲除小鼠的妊娠表型提供了直接证据，表明水通道蛋白缺乏会导致妊娠不良结局。因此，筛选异常妊娠中水通道蛋白的调节成为一种理想的方法。在子痫前期、羊水过多或过少、绒毛膜羊膜炎以及母体营养不良的妊娠中，均可观察到水通道蛋白的改变。尽管水通道蛋白的功能意义仍有待阐明，但它在异常妊娠中的表达和调节提示了针对异常妊娠的潜在治疗策略。
