Radiology Clinic, Tartu University Hospital, Tartu, Estonia; Department of Radiology, University of Tartu, Tartu, Estonia.
Department of Pediatrics, University of Tartu, Tartu, Estonia; Children's Clinic, Tartu University Hospital, Tartu, Estonia.
Brain Lang. 2022 May;228:105108. doi: 10.1016/j.bandl.2022.105108. Epub 2022 Mar 22.
Perinatal stroke affects child's language development and can change language lateralization. Language generation and comprehension tasks in functional magnetic resonance imaging were used to determine language lateralization in term born children with perinatal left-side arterial ischemic stroke (AIS) (n = 9, mean age (SD) 13.4 (3.1) y.) and periventricular venous infarction (PVI) (n = 12, 11.8 (2.8) y.), and in healthy right-handed controls (n = 30, 11.6 (2.6) y.). Lateralization index was calculated for the Broca and Wernicke areas and correlated with language and cognitive outcomes measured by the Kaufman Assessment Battery for Children II ed. Language outcome in children with perinatal stroke is poorer compared to healthy controls. Children with small AIS lesions and most children with PVI showed left-side language activation. Most children with large AIS lesions and one child with large PVI had language activation reorganized to the right hemisphere. Language reorganization to the unlesioned right hemisphere did not ensure normal language outcome.
围产期卒中影响儿童的语言发育，并可能改变语言侧化。使用功能磁共振成像中的语言生成和理解任务来确定足月出生的围产期左侧动脉缺血性卒中（AIS）（n=9，平均年龄（标准差）为 13.4（3.1）岁）和脑室周围静脉梗死（PVI）（n=12，11.8（2.8）岁）儿童以及健康右利手对照者（n=30，11.6（2.6）岁）的语言侧化。为 Broca 和 Wernicke 区计算了侧化指数，并与通过 Kaufman 儿童评估量表第二版（Kaufman Assessment Battery for Children II ed.）测量的语言和认知结果相关联。围产期卒中患儿的语言预后较健康对照组差。小 AIS 病变的患儿和大多数 PVI 患儿表现为左侧语言激活。大多数大 AIS 病变患儿和 1 例大 PVI 患儿的语言激活重新分布至右侧半球。语言向未损伤的右侧半球重新分布并不能确保正常的语言预后。
