Department of Orthopaedic Surgery, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, No.164, Lanxi Road, Putuo District, 200062, Shanghai, China.
Int Orthop. 2013 Oct;37(10):2061-3. doi: 10.1007/s00264-013-1931-4. Epub 2013 Jun 9.
The purpose of this study was to investigate the possible association between single nucleotide polymorphisms (SNPs) rs1800629 (TNF-α -308) and rs361525 (TNF-α -238) of the tumour necrosis factor (TNF)-α gene and susceptibility to osteoarthritis (OA) in the Han Chinese population.
The TNF-α -308 and -238 genotypes were determined by TaqMan assay in 200 OA cases and 305 controls. Odds ratios (ORs) for OA and 95% confidence intervals (CIs) from unconditional logistic regression models were used to evaluate relative risks.
The frequencies of the allele 'A' of rs1800629 were 16% and 8.85% in OA cases and in controls, respectively, and thus the -308A allele had a 1.9612-fold (95% CI = 1.3323-2.8869, P < 0.001) increased risk for OA as compared to the -308G allele. However, no significant differences were found in the genotype and allele frequencies for rs361525 between OA and HC groups.
In the Han Chinese population, the allele 'A' of TNF-α -308 may increase the risk for OA, whereas TNF-α -238 polymorphisms do not play a role in OA patients.
本研究旨在探讨肿瘤坏死因子（TNF）-α 基因中的单核苷酸多态性（SNP）rs1800629（TNF-α-308）和 rs361525（TNF-α-238）与汉族人群骨关节炎（OA）易感性之间的可能关联。
采用 TaqMan 法检测 200 例 OA 患者和 305 例对照者 TNF-α-308 和 -238 基因型。采用非条件 logistic 回归模型计算 OA 的比值比（OR）和 95%置信区间（CI），以评估相对风险。
rs1800629 等位基因“A”在 OA 病例和对照组中的频率分别为 16%和 8.85%，因此-308A 等位基因使 OA 的风险增加 1.9612 倍（95%CI=1.3323-2.8869，P<0.001），与-308G 等位基因相比。然而，OA 和 HC 组之间 rs361525 的基因型和等位基因频率没有差异。
在汉族人群中，TNF-α-308 的等位基因“A”可能增加 OA 的风险，而 TNF-α-238 多态性与 OA 患者无关。
