血管紧张素转换酶I/D多态性与脓毒症之间的关联：一项荟萃分析。
Association between angiotensin-converting enzyme I/D polymorphism and sepsis: A meta-analysis.
作者信息
Hou Xin, Zhang Pan, Nie Wei, Tang Shunjuan, Wang Jiuyan, Zhang Qiong, Wan Zhengdong, Zhang Botao, Song Bin
机构信息
Department of General Surgery, The First People's Hospital of Jingzhou, Jingzhou, China.
Department of Nephrology, The First People's Hospital of Jingzhou, Jingzhou, China.
出版信息
J Renin Angiotensin Aldosterone Syst. 2015 Jun;16(2):415-21. doi: 10.1177/1470320313492361. Epub 2013 Jun 7.
BACKGROUND
Previous studies investigating the association between the angiotensin-converting enzyme I/D polymorphism and sepsis have provided inconsistent results. Thus, a meta-analysis was performed to clarify the effect of the angiotensin-converting enzyme I/D polymorphism on sepsis risk and sepsis-related mortality.
METHODS
A comprehensive literature search was performed. Six case-control studies and two cohort studies were included in this meta-analysis. Odds ratios and corresponding 95% confidence intervals were estimated using random-effects models.
RESULTS
Pooled analysis of six case-control studies showed that there was a significant association between the angiotensin-converting enzyme I/D polymorphism and sepsis risk in a recessive genetic model (odds ratio = 0.75, 95% confidence interval 0.62-0.91, p = 0.004). However, no significant association between the angiotensin-converting enzyme I/D polymorphism and mortality was observed (odds ratio = 0.84, 95% confidence interval 0.57-1.24, p = 0.38).
CONCLUSIONS
Our meta-analysis confirmed that the angiotensin-converting enzyme I/D polymorphism was associated with sepsis risk. However, the angiotensin-converting enzyme I/D polymorphism was not associated with sepsis mortality.
背景
既往研究探讨血管紧张素转换酶I/D多态性与脓毒症之间的关联，结果并不一致。因此，进行了一项荟萃分析，以阐明血管紧张素转换酶I/D多态性对脓毒症风险和脓毒症相关死亡率的影响。
方法
进行了全面的文献检索。本荟萃分析纳入了6项病例对照研究和2项队列研究。采用随机效应模型估计比值比及相应的95%置信区间。
结果
6项病例对照研究的汇总分析显示，在隐性遗传模型中，血管紧张素转换酶I/D多态性与脓毒症风险之间存在显著关联（比值比=0.75，95%置信区间0.62-0.91，p=0.004）。然而，未观察到血管紧张素转换酶I/D多态性与死亡率之间存在显著关联（比值比=0.84，95%置信区间0.57-1.24，p=0.38）。
结论
我们的荟萃分析证实，血管紧张素转换酶I/D多态性与脓毒症风险相关。然而，血管紧张素转换酶I/D多态性与脓毒症死亡率无关。
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