Su Gang, Dou Hengli, Zhao Limei, Wang Hongjie, Liu Guiyang, Huang Bo, Peng Bo
Department of Neurosurgery, The Fourth People's Hospital of Jinan, China.
Department of Neurosurgery, The Fourth People's Hospital of Jinan, China
J Renin Angiotensin Aldosterone Syst. 2015 Jun;16(2):428-33. doi: 10.1177/1470320313494432. Epub 2013 Jul 5.
The angiotensin-converting enzyme (ACE) may be involved in the pathogenesis of Parkinson's disease (PD). There have been several studies investigating the association between ACE gene I/D polymorphism and PD risk, but they reported inconsistent findings. We performed a meta-analysis to investigate the association between ACE gene I/D polymorphism and PD risk.
Published literature from PubMed and Embase databases were searched for eligible publications. Pooled odds ratios (ORs) with 95% confidence intervals (95% CIs) were calculated using random- or fixed-effects models based on between-study heterogeneity.
A total of five studies including 606 cases and 708 controls were finally included in the meta-analysis. Meta-analysis showed that there was no obvious association between ACE gene I/D polymorphism and PD risk under the homogeneous co-dominant model (OR = 1.14, 95% CI = 0.71-1.82), heterogeneous co-dominant model (OR = 0.92, 95% CI = 0.70-1.22), dominant model (OR = 0.99, 95% CI = 0.76-1.28) or recessive model (OR = 1.07, 95% CI = 0.83-1.37).
The meta-analysis suggests that there is no evidence for the association between ACE gene I/D polymorphism and PD risk.
血管紧张素转换酶（ACE）可能参与帕金森病（PD）的发病机制。已有多项研究探讨ACE基因I/D多态性与PD风险之间的关联，但结果并不一致。我们进行了一项荟萃分析，以研究ACE基因I/D多态性与PD风险之间的关联。
检索PubMed和Embase数据库中的已发表文献，寻找符合条件的出版物。根据研究间的异质性，使用随机或固定效应模型计算合并比值比（OR）及其95%置信区间（95%CI）。
荟萃分析最终纳入了5项研究，共606例病例和708例对照。荟萃分析表明，在同质共显性模型（OR = 1.14，95%CI = 0.71 - 1.82）、异质共显性模型（OR = 0.92，95%CI = 0.70 - 1.22）、显性模型（OR = 0.99，95%CI = 0.76 - 1.28）或隐性模型（OR = 1.07，95%CI = 0.83 - 1.37）下，ACE基因I/D多态性与PD风险之间均无明显关联。
荟萃分析表明，没有证据支持ACE基因I/D多态性与PD风险之间存在关联。
