血管紧张素转换酶I/D多态性与2型糖尿病患者糖尿病周围神经病变：一项荟萃分析。
Angiotensin-converting enzyme I/D polymorphism and diabetic peripheral neuropathy in type 2 diabetes mellitus: A meta-analysis.
作者信息
Li Yao, Tong Nanwei
机构信息
Department of Endocrinology, West China Hospital of Sichuan University, Chengdu, Sichuan Province, China.
Department of Endocrinology, West China Hospital of Sichuan University, Chengdu, Sichuan Province, China
出版信息
J Renin Angiotensin Aldosterone Syst. 2015 Dec;16(4):787-92. doi: 10.1177/1470320314539828. Epub 2014 Aug 20.
BACKGROUND
Several molecular epidemiological studies have been conducted to examine the association between angiotensin-converting enzyme (ACE) I/D polymorphism and diabetic peripheral neuropathy (DPN) risk. However, the conclusions remained controversial. We therefore performed this meta-analysis.
METHODS
PubMed and EMBASE were searched to identify case-control studies investigating the associations of ACE I/D polymorphism with risk of DPN. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of association between ACE I/D polymorphism and risk of DPN.
RESULTS
A total of seven case-control studies including 1316 cases and 1617 controls were included. ACE I/D polymorphism was associated with a significantly increased risk of DPN (OR=1.46, 95%CI 1.11-1.92, p=0.006, I(2)=48%). This result remained statistically significant when the adjusted ORs were combined (OR=1.84, 95%CI 1.14-2.99, p=0.01, I(2)=53%). In the subgroup of ethnicity, a significantly elevated risk was observed in Caucasians (OR=1.32, 95%CI 1.10-1.59, p=0.003, I(2)=43%).
CONCLUSIONS
Our meta-analysis confirmed that ACE I/D polymorphism was associated with the risk of DPN.
背景
已经开展了多项分子流行病学研究，以探讨血管紧张素转换酶（ACE）I/D多态性与糖尿病周围神经病变（DPN）风险之间的关联。然而，结论仍存在争议。因此，我们进行了这项荟萃分析。
方法
检索PubMed和EMBASE，以确定调查ACE I/D多态性与DPN风险之间关联的病例对照研究。采用比值比（OR）及其95%置信区间（CI）来评估ACE I/D多态性与DPN风险之间关联的强度。
结果
共纳入7项病例对照研究，包括1316例病例和1617例对照。ACE I/D多态性与DPN风险显著增加相关（OR=1.46，95%CI 1.11-1.92，p=0.006，I²=48%）。当合并调整后的OR时，该结果仍具有统计学意义（OR=1.84，95%CI 1.14-2.99，p=0.01，I²=53%）。在种族亚组中，白种人的风险显著升高（OR=1.32，95%CI 1.10-1.59，p=0.003，I²=43%）。
结论
我们的荟萃分析证实，ACE I/D多态性与DPN风险相关。
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