Department of Dermatology and Photobiology, Andreas Syggros Hospital, University of Athens, 5 I. Dragoumi Street, 16121 Athens, Greece.
J Biomed Opt. 2013 Jun;18(6):061221. doi: 10.1117/1.JBO.18.6.061221.
The importance of dermatological noninvasive imaging techniques has increased over the last decades, aiming at diagnosing nonmelanoma skin cancer (NMSC). Technological progress has led to the development of various analytical tools, enabling the in vivo/in vitro examination of lesional human skin with the aim to increase diagnostic accuracy and decrease morbidity and mortality. The structure of the skin layers, their chemical composition, and the distribution of their compounds permits the noninvasive photodiagnosis of skin diseases, such as skin cancers, especially for early stages of malignant tumors. An important role in the dermatological diagnosis and disease monitoring has been shown for promising spectroscopic and imaging techniques, such as fluorescence, diffuse reflectance, Raman and near-infrared spectroscopy, optical coherence tomography, and confocal laser-scanning microscopy. We review the use of these spectroscopic techniques as noninvasive tools for the photodiagnosis of NMSC.
在过去几十年中，皮肤科非侵入性成像技术的重要性日益增加，旨在诊断非黑色素瘤皮肤癌（NMSC）。技术进步导致了各种分析工具的发展，使人们能够对病变人体皮肤进行体内/体外检查，旨在提高诊断准确性，降低发病率和死亡率。皮肤层的结构、化学成分及其化合物的分布允许对皮肤病（如皮肤癌）进行非侵入性光诊断，特别是对于恶性肿瘤的早期阶段。一些有前途的光谱和成像技术，如荧光、漫反射、拉曼和近红外光谱、光学相干断层扫描和共聚焦激光扫描显微镜，在皮肤科诊断和疾病监测中发挥了重要作用。我们综述了这些光谱技术作为 NMSC 光诊断的非侵入性工具的应用。
