Kurisu Manami, Miyamae Yusaku, Murakami Kazuma, Han Junkyu, Isoda Hiroko, Irie Kazuhiro, Shigemori Hideyuki
Graduate School of Life and Environmental Sciences, University of Tsukuba, Ibaraki, Japan.
Biosci Biotechnol Biochem. 2013;77(6):1329-32. doi: 10.1271/bbb.130101. Epub 2013 Jun 7.
We examined the effects of acteoside (1a), which was isolated from Orobanche minor, and its derivatives on the aggregation of a 42-mer amyloid β protein (Aβ42) in our search for anti-amyloidogenic compounds for Alzheimer's disease (AD) therapy. Acteoside (1a) strongly inhibited the aggregation of Aβ42 in a dose-dependent manner. The structure-activity relationship for acteoside (1a) and related compounds suggests the catechol moiety of phenylethanoid glycosides to be essential for this inhibitory activity.
我们研究了从小列当分离得到的阿克苷（1a）及其衍生物对42聚体淀粉样β蛋白（Aβ42）聚集的影响，以寻找用于阿尔茨海默病（AD）治疗的抗淀粉样蛋白生成化合物。阿克苷（1a）以剂量依赖性方式强烈抑制Aβ42的聚集。阿克苷（1a）及相关化合物的构效关系表明，苯乙醇苷的儿茶酚部分对这种抑制活性至关重要。
