Clinic of Internal Medicine/Nephrology, Bagcilar Training and Research Hospital, 34200, Bagcılar, Istanbul, Turkey,
Int Urol Nephrol. 2014 Jan;46(1):57-62. doi: 10.1007/s11255-013-0481-4. Epub 2013 Jun 8.
Indications of dialysis treatment for patients with end-stage renal disease depend on various clinical and laboratory parameters. In this study, we aimed to determine whether standardized serum cystatin C (SCC) equation may be an applicability of marker for dialysis initiation and its relationship to other clearance values among patients with advanced chronic kidney disease.
A total of 84 patients (45 males, 39 females) aged 19-89 were evaluated in this study. Hemodialysis was indicated according to clinical and laboratory findings, and estimated glomerular filtration rate (eGFR) was according to four different formulas [MDRD, EpiCKD, Cockcroft Gault formula (CGF) and SCC equation].
eGFR values of patients in the study were 7.23 ± 3.26, 7.86 ± 3.78, 15.09 ± 10.88 and 11.31 ± 4.54 according to MDRD, EpiCKD, SCC equation and CGF, respectively. There was a positive correlation between MDRD, EpiCKD and CGF, and between EpiCKD and CGF (p < 0.01). Also, statistically significant correlation was found between SCC equation and CGF (p < 0.05).
SCC equation was not seemed to be an appropriate marker for starting dialysis in patients with advanced CKD.
终末期肾病患者进行透析治疗的指征取决于各种临床和实验室参数。在本研究中，我们旨在确定标准化血清胱抑素 C（SCC）方程是否可作为开始透析的适用性标志物，并研究其与晚期慢性肾脏病患者其他清除率值的关系。
本研究共评估了 84 名患者（45 名男性，39 名女性），年龄 19-89 岁。根据临床和实验室发现，指示进行血液透析，并根据四个不同公式[MDRD、EpiCKD、 Cockcroft-Gault 公式（CGF）和 SCC 方程]估算肾小球滤过率（eGFR）。
研究中患者的 eGFR 值分别为根据 MDRD、EpiCKD、SCC 方程和 CGF 公式计算的 7.23±3.26、7.86±3.78、15.09±10.88 和 11.31±4.54。MDRD、EpiCKD 和 CGF 之间以及 EpiCKD 和 CGF 之间呈正相关（p<0.01）。此外，SCC 方程与 CGF 之间也存在统计学显著相关性（p<0.05）。
SCC 方程似乎不是晚期 CKD 患者开始透析的合适标志物。
