Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, London, United Kingdom.
Hippocampus. 2013 Oct;23(10):849-54. doi: 10.1002/hipo.22155. Epub 2013 Jun 27.
The hippocampus has long been implicated in supporting autobiographical memories, but little is known about how they are instantiated in hippocampal subfields. Using high-resolution functional magnetic resonance imaging (fMRI) combined with multivoxel pattern analysis we found that it was possible to detect representations of specific autobiographical memories in individual hippocampal subfields. Moreover, while subfields in the anterior hippocampus contained information about both recent (2 weeks old) and remote (10 years old) autobiographical memories, posterior CA3 and DG only contained information about the remote memories. Thus, the hippocampal subfields are differentially involved in the representation of recent and remote autobiographical memories during vivid recall.
海马体长期以来一直被认为对支持自传体记忆起着重要作用，但人们对它们在海马亚区中的具体表现形式知之甚少。使用高分辨率功能磁共振成像（fMRI）结合多体素模式分析，我们发现有可能在单个海马亚区中检测到特定自传体记忆的表示。此外，虽然前海马亚区包含了近期（2 周前）和远期（10 年前）自传体记忆的信息，但 CA3 和 DG 后区仅包含了远期记忆的信息。因此，在生动的回忆中，海马亚区在最近和遥远的自传体记忆的表现上存在差异。
