Mattsson T, Anneroth G, Köndell P A, Nordenram A
Department of Oral Surgery, School of Dentistry, Karolinska Institutet, Stockholm, Sweden.
Swed Dent J. 1990;14(2):57-62.
The search for a biodegradable material which may prevent or stop bleeding in bone tissue and ensure healing is of continuous interest. ACP, an absorbable collagen paste, is a new hemostatic agent. The present study was devised to compare ACP with another commonly used hemostatic agent, Surgicel, in order to determine the tissue response during bone healing. The materials were implanted in the mandibular bone of New Zealand white rabbits. The observation times were 1, 2, 4 and 8 weeks. The result showed that the healing was uneventful for both the hemostatic agents even though healing was slightly retarded compared to natural healing. Both the hemostatic agents were completely resorbed within 4-8 weeks and also the bone healing was completed after this observation period.
寻找一种可生物降解的材料，用于预防或阻止骨组织出血并确保愈合，一直是人们持续关注的问题。ACP（一种可吸收的胶原蛋白糊剂）是一种新型止血剂。本研究旨在将ACP与另一种常用止血剂Surgicel进行比较，以确定骨愈合过程中的组织反应。将这些材料植入新西兰白兔的下颌骨。观察时间为1、2、4和8周。结果表明，尽管与自然愈合相比愈合略有延迟，但两种止血剂的愈合过程均顺利。两种止血剂在4-8周内完全吸收，在此观察期后骨愈合也完成。
