*Paediatric Gastroenterology †Department of Clinical Chemistry, Microbiology and Immunology, Laboratory of Clinical Biology ‡Adult Gastroenterology, Ghent University Hospital, Belgium.
J Pediatr Gastroenterol Nutr. 2013 Oct;57(4):489-92. doi: 10.1097/MPG.0b013e31829d4e9e.
Anti-neutrophil cytoplasmic antibodies (ANCAs) detected by indirect immunofluorescence have been found in patients with inflammatory bowel disease (IBD). Nevertheless, specific antibodies against proteinase-3 (PR3) are rare in this context.
Sera from 30 consecutive pediatric patients with IBD were evaluated for ANCA-indirect immunofluorescence and its specific antibodies to investigate whether PR3-ANCA positivity (PR3-ANCA+) identifies a distinct IBD subtype.
The 5 PR3-ANCA+ patients (17%) showed significantly more concomitant biliary disease and severe anal blood loss (P < 0.05). None had vasculitis features at diagnosis nor during follow-up.
This pilot study demonstrates significant clinical differences between the PR3-ANCA-positive and -negative IBD subset.
通过间接免疫荧光法检测到的抗中性粒细胞胞浆抗体（ANCA）已在炎症性肠病（IBD）患者中发现。然而，在这种情况下，针对蛋白酶 3（PR3）的特异性抗体很少见。
评估了 30 例连续的儿科 IBD 患者的血清，以进行 ANCA-间接免疫荧光及其特异性抗体检测，以研究 PR3-ANCA 阳性（PR3-ANCA+）是否可确定一个独特的 IBD 亚型。
5 例 PR3-ANCA+患者（17%）同时伴有明显更多的胆道疾病和严重的肛门血便（P < 0.05）。在诊断时和随访期间，均无血管炎特征。
这项初步研究表明，PR3-ANCA 阳性和阴性的 IBD 亚组之间存在显著的临床差异。
