da Silva Severino Lourenço, Pitta Guilherme Benjamin Brandão, Pereira Adamastor Humberto, Castro Aldemar de Araújo, de Matos Maria Helena Tavares, Silveira Fábio Duque, Magalhães Leonardo Torres, de Moraes José Adolfo Hurt Almeida, Machado Emmylena Karina Cordeiro, Wanderley Carlos Wagner de Souza, Silva Camila Meirelles de Souza, dos Santos Luciana da Paz, Nogueira João Nicolle Tupiná
Surgical Clinics, Federal University of Vale do São Francisco, Petrolina, Pernambuco State, Brazil.
Rev Col Bras Cir. 2013 Mar-Apr;40(2):130-6. doi: 10.1590/s0100-69912013000200009.
To develop an experimental model of stable saccular aneurysm in carotid of pigs using the internal jugular vein.
In 12 healthy pigs, weighing between 25 and 5 0kg, five males and seven females, we made a right common carotid artery aneurysm. After elliptical arteriotomy, we carried out a terminolateral anastomosis with the distal stump of the internal jugular vein. Aneurysm volume was calculated so that the value did not exceed 27 times the area of the arteriotomy. After six days angiography and microscopic examination were performed to assess patency of the aneurysm and the presence of total or partial thrombosis.
There was a significant weight gain of pigs in the time interval between the manufacture of the aneurysm and angiography (p = 0.04). Aneurysmal patency was observed in ten pigs (83%). Operative wound infections occurred in two animals (16.6%), both with early onset, three days after the making of the aneurysm. Histological analysis showed aneurysm thrombus partially occluding the light in nine pigs (75%). In these animals, it was observed that on average 9% of the aneurysmal diameter was filled with thrombi.
It was possible to develop a stable experimental model of saccular aneurysms in pig carotid artery by use of the internal jugular vein.
利用颈内静脉建立猪颈动脉囊状动脉瘤的实验模型。
选取12头体重在25至50千克之间的健康猪，其中雄性5头，雌性7头，制作右侧颈总动脉瘤。在进行椭圆形动脉切开术后，将颈内静脉远端残端与动脉进行端侧吻合。计算动脉瘤体积，使其值不超过动脉切开面积的27倍。6天后进行血管造影和显微镜检查，以评估动脉瘤的通畅情况以及是否存在完全或部分血栓形成。
在动脉瘤制作与血管造影之间的时间段内，猪的体重显著增加（p = 0.04）。10头猪（83%）观察到动脉瘤通畅。2只动物（16.6%）发生手术伤口感染，均为早期发病，即在动脉瘤制作后3天。组织学分析显示，9头猪（75%）的动脉瘤血栓部分阻塞管腔。在这些动物中，观察到平均动脉瘤直径的9%被血栓填充。
利用颈内静脉有可能建立猪颈动脉囊状动脉瘤的稳定实验模型。
