Suárez-Varela María Morales, García-Marcos Luís, Fernández-Espinar Javier Fuertes, Bercedo-Sanz Alberto, Aguinaga-Ontoso Inés, González-Díaz Carlos, Carvajal-Urueña Ignacio, Busquet-Monge Rosa María, Arnedo-Pena Alberto, García de Andoin Nagore, Batlles-Garrido José, Blanco-Quirós Alfredo, López-Silvarrey Varela Angel, García-Hernández Gloria, Gimeno-Clemente Natalia, Rubio-López Nuria, Llopis-González Agustín
Public and Environmental Health Unit, Department of Preventive Medicine, University of Valencia. CIBER Epidemiology and Public Health (CIBERESP), and Center for Public Health Research (CSISP), Valencia, Spain.
Iran J Allergy Asthma Immunol. 2013 May 15;12(2):115-23.
Atopic Eczema (AE) is a chronic inflammatory skin disease that affects children and adults, and alters quality of life. Previous studies have suggested several socio-demographic and environmental factors related to the prevalence of AE and other allergic diseases, including acetaminophen use. In the present study, we report the rates of isolated AE, AE associated with asthma and AE associated with rhinitis among 13- to 14-year-old Spanish adolescents and the level of association of these conditions with the use of acetaminophen. We analyzed Spanish data from a cross-sectional Phase 3 study within ISAAC. A total of 28,717 adolescents completed the Phase 3 written questionnaire by answering questions for acetaminophen use and on asthma, rhinitis and AE symptoms.We observed an association between acetaminophen use and AE among the adolescents who had used acetaminophen in the previous month. Furthermore, the prevalence rate increased with the number of allergic processes: for AE alone, the adjusted Prevalence Ratio (aPR) was 1.81 and for AE associated with rhinitis or with asthma, aPRs were 2.20 and 3.03, respectively.We conclude that acetaminophen use in childhood may be an important factor associated with development and/or maintenance of AE and other allergic diseases.
特应性皮炎（AE）是一种影响儿童和成人的慢性炎症性皮肤病，会改变生活质量。先前的研究表明，有几个社会人口统计学和环境因素与AE及其他过敏性疾病的患病率有关，包括对乙酰氨基酚的使用。在本研究中，我们报告了13至14岁西班牙青少年中单纯性AE、与哮喘相关的AE以及与鼻炎相关的AE的发生率，以及这些病症与对乙酰氨基酚使用的关联程度。我们分析了国际儿童哮喘和过敏研究（ISAAC）中一项横断面3期研究的西班牙数据。共有28717名青少年通过回答有关对乙酰氨基酚使用以及哮喘、鼻炎和AE症状的问题，完成了3期书面问卷。我们观察到，在前一个月使用过对乙酰氨基酚的青少年中，对乙酰氨基酚的使用与AE之间存在关联。此外，患病率随着过敏过程的数量增加而上升：仅就AE而言，调整后的患病率比值（aPR）为1.81，而与鼻炎或哮喘相关的AE，aPR分别为2.20和3.03。我们得出结论，儿童期使用对乙酰氨基酚可能是与AE及其他过敏性疾病的发生和/或维持相关的一个重要因素。
