Bone and Joint Center, Henry Ford Hospital, Detroit, Michigan, USA.
J Orthop Res. 2013 Sep;31(9):1333-44. doi: 10.1002/jor.22397. Epub 2013 Jun 10.
microRNAs are small non-coding RNAs that in the last decade have emerged as overarching regulators of gene expression. Their abundance, ability to repress a large number of target genes and overlapping target specificity indicate a complex network of interactions that is still being defined. A number of studies focused on the role of microRNAs in cartilage have identified a small number, including miR-140 and -675 as playing important roles in regulation of cartilage homeostasis and together with the broader description of the activity of microRNAs in other tissues are beginning to define the function of microRNAs in cartilage development and homeostasis.
microRNAs 是小的非编码 RNA，在过去十年中作为基因表达的总体调控因子出现。它们的丰度、抑制大量靶基因的能力和重叠的靶特异性表明，这是一个仍在定义的复杂相互作用网络。许多研究集中在 microRNAs 在软骨中的作用，已经确定了一小部分，包括 miR-140 和 -675，它们在软骨内稳态的调节中发挥重要作用，并且与 microRNAs 在其他组织中的活性的更广泛描述一起，开始定义 microRNAs 在软骨发育和内稳态中的功能。
