Center for Colorectal Cancer, Research Institute and Hospital of National Cancer Center, Goyang-si, Korea.
Cancer Causes Control. 2012 May;23(5):727-35. doi: 10.1007/s10552-012-9942-9. Epub 2012 Mar 27.
Recently, some studies have shown that diabetes mellitus and metabolic syndrome increase the risk of colorectal neoplasms. Although the mechanism is not known, those have been proposed to contribute to this phenomenon, including insulin resistance, oxidative stress, and adipokine production. The objective of this study was to assess the association between metabolic risk factors and colorectal neoplasm.
Study participants visited the National Cancer Center, Korea, for screening (2007-2009). A total of 1,771 diagnosed adenoma patients and 4,667 polyp-free controls were included. The association between risk factors and colorectal neoplasm was evaluated using logistic regression models.
High waist circumference, blood pressure, and serum triglyceride levels were associated with an increased risk of colorectal adenoma. Metabolic syndrome (MS) was associated with an increased risk of adenoma (OR = 1.44, 95 % CI = 1.23-1.70). The association between MS and colorectal adenoma was observed regardless of advanced/low-risk adenoma, and multiplicity. MS affected right colon adenomas (OR = 1.50, 95 % CI = 1.22-1.85), left colon adenomas (OR = 1.36, 95 % CI = 1.05-1.76), and adenomas in multiple anatomical locations (OR = 1.59, 95 % CI = 1.19-2.12), but was not associated with rectum.
Central obesity, triglyceride level, and MS are risk factors for colorectal adenoma including advanced adenoma and multiplicity.
最近的一些研究表明，糖尿病和代谢综合征会增加结直肠肿瘤的风险。虽然其机制尚不清楚，但有研究提出，胰岛素抵抗、氧化应激和脂肪因子生成等因素可能与此现象有关。本研究旨在评估代谢危险因素与结直肠肿瘤之间的关联。
研究对象于 2007 年至 2009 年期间前往韩国国家癌症中心进行筛查。共纳入 1771 例确诊为腺瘤的患者和 4667 例无息肉对照者。采用 logistic 回归模型评估危险因素与结直肠肿瘤之间的关联。
高腰围、血压和血清甘油三酯水平与结直肠腺瘤风险增加相关。代谢综合征（MS）与腺瘤风险增加相关（OR=1.44，95%CI=1.23-1.70）。无论腺瘤为高级别/低级别还是多发性，MS 均与结直肠腺瘤风险增加相关。MS 影响右半结肠腺瘤（OR=1.50，95%CI=1.22-1.85）、左半结肠腺瘤（OR=1.36，95%CI=1.05-1.76）和多部位解剖位置的腺瘤（OR=1.59，95%CI=1.19-2.12），但与直肠无关。
中心性肥胖、甘油三酯水平和 MS 是结直肠腺瘤（包括高级别腺瘤和多发性腺瘤）的危险因素。
