School of Cellular and Molecular Medicine, University of Bristol , Bristol , UK.
Front Immunol. 2013 May 31;4:129. doi: 10.3389/fimmu.2013.00129. eCollection 2013.
Since the discovery of interleukin-10 (IL-10) in the 1980s, a large body of work has led to its recognition as a pleiotropic immunomodulatory cytokine that affects both the innate and adaptive immune systems. IL-10 is produced by a wide range of cell types, but for the purposes of this review we shall focus on IL-10 secreted by CD4(+) T cells. Here we describe the importance of IL-10 as a mediator of suppression used by both FoxP3(+) and FoxP3(-) T regulatory cells. Moreover, we discuss the molecular events leading to the induction of IL-10 secretion in T helper cell subsets, where it acts as a pivotal negative feedback mechanism. Finally we discuss how a greater understanding of this principle has allowed for the design of more efficient, antigen-specific immunotherapy strategies to exploit this natural phenomenon clinically.
自 20 世纪 80 年代发现白细胞介素-10（IL-10）以来，大量研究使其被认为是一种多效免疫调节细胞因子，影响固有免疫和适应性免疫系统。IL-10 由多种细胞类型产生，但为了本综述的目的，我们将重点关注 CD4(+) T 细胞分泌的 IL-10。在这里，我们描述了 IL-10 作为 FoxP3(+) 和 FoxP3(-)T 调节细胞使用的抑制介质的重要性。此外，我们讨论了导致辅助性 T 细胞亚群中 IL-10 分泌的分子事件，其中它作为关键的负反馈机制发挥作用。最后，我们讨论了如何更好地理解这一原理，从而设计出更有效的、针对抗原的免疫治疗策略，从临床上利用这一自然现象。
