调节性 T 细胞整合环境线索控制炎症。
Control of inflammation by integration of environmental cues by regulatory T cells.
机构信息
Howard Hughes Medical Institute and Immunology Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.
出版信息
J Clin Invest. 2013 Mar;123(3):939-44. doi: 10.1172/JCI57175. Epub 2013 Mar 1.
Abstract
Tregs have been implicated in control of homeostasis in the immune system and beyond. These cells restrain inflammatory responses to self antigens, commensal microorganisms, allergens, and pathogens and adapt their homeostatic and functional capabilities to a particular environment. In this review, we discuss a general model of integration of environmental cues by Tregs in which specialized Treg homeostatic, migratory, and suppression programs are established in dynamically changing inflammatory environments by maintaining an optimal threshold of activation of transcription factors involved in regulation of the corresponding type of effector immune responses.
摘要
调节性 T 细胞（Tregs）在免疫系统的稳态控制中发挥作用，这一点已得到证实。这些细胞可抑制对自身抗原、共生微生物、过敏原和病原体的炎症反应，并根据特定环境来调节其自身的稳态和功能能力。在这篇综述中，我们讨论了 Tregs 整合环境线索的一般模型，即在动态变化的炎症环境中，通过维持参与调节相应类型效应免疫反应的转录因子的最佳激活阈值，Tregs 建立了专门的 Treg 稳态、迁移和抑制程序。
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