Department of Biochemistry and Molecular Biology, School of Medicine, The University of New Mexico Health Sciences Center, Albuquerque, NM, USA.
Nutrition. 2013 Sep;29(9):1159-65. doi: 10.1016/j.nut.2013.02.012. Epub 2013 Jun 4.
The goal of this study was to investigate the effects of a high-fat diet supplemented with fish oil or olive oil, fed to C57BL/6J mice for an extended period, on metabolic features associated with type 2 diabetes.
Mice were fed one of four diets for 30 wk: a low-fat diet, a high-fat diet supplemented with lard, a high-fat diet supplemented with fish oil, or a high-fat diet supplemented with olive oil. Phenotypic and metabolic analysis were determined at 15 and 25 to 30 wk, thereby providing comparative analysis for weight gain, energy consumption, fat distribution, glucose and insulin tolerance, and hepatic/plasma lipid analysis.
Mice fed a high-fat diet supplemented with fish oil had improved glucose tolerance after an extended period compared with mice fed a high-fat diet supplemented with lard. Moreover, mice fed a high-fat diet supplemented with fish oil had significantly decreased concentrations of liver cholesterol, cholesteryl ester, and triacylglycerol compared with mice fed a high-fat diet supplemented with either lard or olive oil.
Mice fed a high-fat diet supplemented with fish oil improved metabolic features associated with type 2 diabetes such as impaired glucose tolerance and hepatic steatosis.
本研究旨在探讨高脂肪饮食补充鱼油或橄榄油对 C57BL/6J 小鼠 2 型糖尿病相关代谢特征的影响。
将小鼠分为四组，分别喂食四种不同的饮食，为期 30 周：低脂饮食、富含猪油的高脂肪饮食、富含鱼油的高脂肪饮食和富含橄榄油的高脂肪饮食。在 15 至 25 至 30 周时进行表型和代谢分析，从而对体重增加、能量消耗、脂肪分布、葡萄糖和胰岛素耐量以及肝/血浆脂质分析进行比较分析。
与喂食富含猪油的高脂肪饮食的小鼠相比，喂食富含鱼油的高脂肪饮食的小鼠在延长时间后葡萄糖耐量得到改善。此外，与喂食富含猪油或橄榄油的高脂肪饮食的小鼠相比，喂食富含鱼油的高脂肪饮食的小鼠肝脏胆固醇、胆固醇酯和三酰甘油浓度显著降低。
喂食富含鱼油的高脂肪饮食的小鼠改善了与 2 型糖尿病相关的代谢特征，如葡萄糖耐量受损和肝脂肪变性。
