Division of Pulmonary and Critical Care Medicine, Department of Medicine, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, USA.
Curr Opin Microbiol. 2013 Jun;16(3):327-38. doi: 10.1016/j.mib.2013.05.005. Epub 2013 Jun 8.
By integrating stress signals with inputs from other cellular organelles, eukaryotic mitochondria are dynamic sensing systems that can confer substantial impact on innate immune signaling in both health and disease. This review highlights recently discovered elements of innate immune receptor signaling (TLR, RLR, NLR, and CLR) associated with mitochondrial function and discusses the role of mitochondria in the initiation and/or manifestation of inflammatory diseases and disorders. We also highlight the role of mitochondria as therapeutic targets for inflammatory disease.
通过将应激信号与来自其他细胞细胞器的输入整合在一起，真核线粒体成为动态感应系统，可以在健康和疾病中对先天免疫信号产生重大影响。本综述强调了与线粒体功能相关的先天免疫受体信号（TLR、RLR、NLR 和 CLR）的最新发现元素，并讨论了线粒体在炎症性疾病和紊乱的发生和/或表现中的作用。我们还强调了线粒体作为炎症性疾病治疗靶点的作用。
