Center for Research on Population Health, National Institute of Public Health, Mexico City, Mexico.
Diabetes Care. 2013 Sep;36(9):2720-5. doi: 10.2337/dc12-2173. Epub 2013 Jun 11.
The objective of this study was to evaluate the relationship between childhood and adult secondhand smoke and type 2 diabetes.
We conducted a prospective cohort study among 37,343 French women from the E3N-EPIC (Etude Epidémiologique auprès des femmes de la Mutuelle Générale de l'Education Nationale-European Prospective Investigation into Cancer and Nutrition) who never smoked and who were free of type 2 diabetes, cancer, or cardiovascular disease at baseline in 1992. Self-reported childhood secondhand smoke exposure was defined as having at least one parent who smoked. Adult secondhand smoke was defined as the sum of self-reported hours recorded at baseline of exposure to tobacco smoke from a spouse who smoked (or domestic close contact) and from outside the home.
Between 1992 and 2007, 795 cases of incident type 2 diabetes were identified and validated through a drug reimbursement dataset and a specific questionnaire. Women with at least one parent who smoked appeared to have an 18% higher rate of type 2 diabetes than women with parents who did not smoke (age-adjusted hazard ratio 1.18 [95% CI 1.02-1.36]). Adult secondhand smoke exposure (no exposure versus ≥ 4 h/day) was associated with an increased rate of type 2 diabetes (1.36 [1.05-1.77], P = 0.002 for trend) after adjusting for parental history of diabetes, education, body silhouette at age 8, childhood secondhand smoke exposure, physical activity, body mass index, hypertension, hypercholesterolemia, menopausal status and hormone use, alcohol intake, and processed red meat and coffee consumption.
This prospective analysis suggests that secondhand smoke exposure in childhood and adulthood are associated with a higher rate of type 2 diabetes.
本研究旨在评估儿童期和成年期二手烟与 2 型糖尿病之间的关系。
我们对 37343 名从未吸烟且在 1992 年基线时无 2 型糖尿病、癌症或心血管疾病的法国女性进行了一项前瞻性队列研究。自我报告的儿童期二手烟暴露定义为至少有一位吸烟的父母。成年二手烟暴露定义为自我报告的在家中接触吸烟（或亲密的家庭接触者）和家庭外吸烟的伴侣记录的暴露小时数的总和。
在 1992 年至 2007 年间，共确诊并通过药物报销数据集和特定问卷验证了 795 例 2 型糖尿病新发病例。与父母不吸烟的女性相比，至少有一位吸烟父母的女性患 2 型糖尿病的风险似乎高出 18%（年龄调整后的危险比为 1.18[95%CI1.02-1.36]）。在调整了父母糖尿病病史、教育程度、8 岁时的体型、儿童期二手烟暴露、体力活动、体重指数、高血压、高胆固醇血症、绝经状态和激素使用、饮酒以及加工红肉和咖啡摄入量后，成年二手烟暴露（无暴露与≥4 小时/天）与 2 型糖尿病的发生率增加相关（趋势 P=0.002，1.36[1.05-1.77]）。
这项前瞻性分析表明，儿童期和成年期二手烟暴露与 2 型糖尿病的发生率增加有关。
