Department of Bioscience & Biotechnology, Banasthali University, Banasthali, Rajasthan, India, 304022.
J Environ Pathol Toxicol Oncol. 2013;32(1):1-7. doi: 10.1615/jenvironpatholtoxicoloncol.2013006793.
In this study, we evaluated the protective activity of aqueous extract of jaggery against CCl4-induced hepatic-renal damage in rats. Jaggery was administered in one group at doses of 250, 500 and 750 mg/ kg body weight (bwt) (p.o., once only), and CCL4 was administered in another group at a dose of 1.5 ml/kg bwt (i.p., once only) to evaluate the protective effect of jaggery on induced oxidative damage in rats. Various blood and tissue biochemical studies were performed. The administration of toxicant significantly altered blood biochemical variables. Hepatic and renal lipid peroxidation (LPO) levels increased significantly, whereas considerable depletion was observed in reduced glutathione (GSH) level after intoxication. A remarkable decrease was observed in the activities of adenosine triphosphatase (ATPase) and glucose-6-phosphatase (G-6-Pase) after induction of toxicity. Treatment with extract at three different altered all measured biochemical variables, but greater hepatic-renal protection was observed at higher doses (750 mg/kg bwt) than at lower does (250 and 500 mg/kg bwt). Jaggery also reversed histopathological alterations. Thus, it may be concluded that jaggery can be used to reduce hepatic and renal damage and may serve as an alternative medicine in hepatic and renal etiology.
在这项研究中，我们评估了甘蔗汁水提取物对 CCl4 诱导的大鼠肝肾功能损伤的保护活性。一组大鼠给予 250、500 和 750mg/kg 体重（p.o.，单次给药）的甘蔗汁，另一组大鼠给予 1.5ml/kg 体重（i.p.，单次给药）的 CCl4，以评估甘蔗汁对诱导的大鼠氧化损伤的保护作用。进行了各种血液和组织生化研究。毒物的给予显著改变了血液生化变量。肝和肾的脂质过氧化（LPO）水平显著增加，而中毒后谷胱甘肽（GSH）水平明显耗竭。毒性诱导后，三磷酸腺苷酶（ATPase）和葡萄糖-6-磷酸酶（G-6-Pase）的活性显著下降。提取物在三种不同剂量下处理后，所有测量的生化变量都发生了改变，但在较高剂量（750mg/kg 体重）下比在较低剂量（250 和 500mg/kg 体重）下观察到更大的肝肾功能保护作用。甘蔗汁还逆转了组织病理学改变。因此，可以得出结论，甘蔗汁可用于减少肝肾功能损伤，并可作为肝肾功能病因的替代药物。
