Department of Anesthesiology, University of Florida, College of Medicine, Gainesville, Florida 32610, United States.
ACS Chem Neurosci. 2013 Aug 21;4(8):1151-62. doi: 10.1021/cn400094w. Epub 2013 Jun 24.
Resveratrol, a natural stilbene present at relatively high concentrations in grape skin and seeds and red wine, is known for its purported antioxidant activity in the vascular and nervous systems. In contrast to its direct antioxidant role within the central nervous system, recent research supports a protective mechanism through increasing endogenous cellular antioxidant defenses, which triggers a cascade of parallel neuroprotective pathways. A growing body of in vitro and in vivo evidence indicates that resveratrol acts through multiple pathways and reduces ischemic damage in vital organs, such as the heart and the brain, in various rodent models. Most of the protective biological actions of resveratrol have been associated with its antioxidative, anti-inflammatory, and antiapoptotic properties and other indirect pathways. Continued public interest and increasing resveratrol supplements on the market warrant a review of the available in vitro and in vivo science reported in the stroke-related literature. Rigorous clinical trials evaluating the effects of resveratrol in stroke are absent, though the general population consumption appears to be relatively safe. Resveratrol has shown potential for treating stroke in laboratory animals and in vitro human cell studies, yet there is still a need for human research in preclinical settings. This review summarizes many of the findings on the neuroprotective potential of resveratrol in cerebral stroke, focusing on both the in vitro and in vivo experimental models and some proposed mechanisms of action.
白藜芦醇是一种天然的芪类化合物，在葡萄皮和种子以及红酒中含量相对较高，因其在血管和神经系统中的抗氧化活性而闻名。与它在中枢神经系统中的直接抗氧化作用相反，最近的研究支持了一种通过增加内源性细胞抗氧化防御的保护机制，这触发了一系列平行的神经保护途径。越来越多的体外和体内证据表明，白藜芦醇通过多种途径发挥作用，并减少各种啮齿动物模型中重要器官（如心脏和大脑）的缺血损伤。白藜芦醇的大多数保护生物学作用都与其抗氧化、抗炎和抗细胞凋亡特性以及其他间接途径有关。持续的公众兴趣和市场上不断增加的白藜芦醇补充剂需要对中风相关文献中报告的可用体外和体内科学进行审查。尽管一般人群的消费似乎相对安全，但仍缺乏评估白藜芦醇对中风影响的严格临床试验。白藜芦醇在实验室动物和体外人类细胞研究中显示出治疗中风的潜力，但在临床前环境中仍需要进行人体研究。本综述总结了许多关于白藜芦醇在脑卒中有神经保护潜力的研究结果，重点介绍了体外和体内实验模型以及一些拟议的作用机制。
