Transplantation and Nephrology, Erasmus MC, Rotterdam, The Netherlands.
Transplantation. 2013 Aug 15;96(3):234-8. doi: 10.1097/TP.0b013e318298f9fa.
The Fourth Expert Meeting of the Mesenchymal Stem Cells in Solid Organ Transplantation (MiSOT) Consortium took place in Barcelona on October 19 and 20, 2012. This meeting focused on the translation of preclinical data into early clinical settings. This position paper highlights the main topics explored on the safety and efficacy of mesenchymal stem cells as a therapeutic agent in solid organ transplantation and emphasizes the issues (proper timing, concomitant immunossupression, source and immunogenicity of mesenchymal stem cells, and oncogenicity) that have been addressed and will be followed up by the MiSOT Consortium in future studies.
2012 年 10 月 19 日至 20 日,实体器官移植间充质干细胞(MiSOT)联盟第四次专家会议在巴塞罗那举行。本次会议重点关注将临床前数据转化为早期临床环境。本立场文件强调了在实体器官移植中作为治疗剂的间充质干细胞的安全性和有效性方面探索的主要主题,并强调了 MiSOT 联盟在未来研究中将要解决和跟进的问题(适当的时机、伴随免疫抑制、间充质干细胞的来源和免疫原性以及致癌性)。