紧密连接蛋白与胃癌发生。

Claudins and gastric carcinogenesis.

机构信息

Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore.

出版信息

Exp Biol Med (Maywood). 2013 Apr;238(4):344-9. doi: 10.1177/1535370213477981.

Abstract

Gastric carcinoma arises from aberrant growth of normal gastric mucosa. There is increasing evidence that claudins (CLDNs) may play a critical role in the significant steps of gastric tumorigenesis, from metaplasia to metastasis. The CLDN family which consists of at least 27 member proteins is known to mediate selective permeability in cellular tight junctions. It is now established that CLDNs are differentially altered in gastric cancer and CLDN proteins are believed to play different roles in the growth and progression of gastric cancer.

摘要

胃癌起源于正常胃黏膜的异常生长。越来越多的证据表明，紧密连接蛋白（CLDNs）可能在胃肿瘤发生的重要步骤中发挥关键作用，从化生到转移。CLDN 家族由至少 27 种成员蛋白组成，已知其在细胞紧密连接中介导选择性通透性。现已确定 CLDNs 在胃癌中存在差异改变，并且 CLDN 蛋白被认为在胃癌的生长和进展中发挥不同的作用。