Department of Dermatology, Yıldırım Beyazıt University, Ankara, Turkey,
Am J Clin Dermatol. 2013 Oct;14(5):421-5. doi: 10.1007/s40257-013-0034-8.
Chronic inflammatory diseases such as psoriasis, rheumatoid arthritis, and inflammatory bowel diseases have been reported to be associated with the development of metabolic syndrome (MetS), which is characterized by central obesity, elevated triglycerides (TG), reduced high-density lipoproteins (HDL), impaired fasting blood glucose (FBG), and hypertension. Behçet disease (BD) is a chronic, immuno-inflammatory disease with multisystemic involvement.
The aim of this study was to investigate the prevalence and risk factors for MetS in patients with BD.
All patients had BD according to the criteria of the International Study Group. Diagnosis of MetS was established according to National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) criteria. Mean waist circumference, body mass index (BMI), FBG, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), total cholesterol, HDL, very low-density lipoprotein (VLDL), low-density lipoprotein (LDL), TG, systolic BP, and diastolic BP were measured and analyzed.
A total of 86 patients and 72 healthy controls were included. MetS was detected in 35.4 % of patients and 20 % of controls (p = 0.04). Patients with BD had a 2.67-fold higher risk for MetS than healthy controls (p < 0.05). Significant risk factors for developing MetS according to multivariate analyses were BD, age, and BMI. Age at onset of the disease, duration of disease, BMI, gastrointestinal system involvement, and neurological involvement were correlated with increased MetS risk (p < 0.05). MetS tended to increase with age and the duration of the disease and was higher in women under the age of 40 years compared with healthy controls in the same age group.
All BD patients should be closely monitored for hypertension, hyperlipidemia, and diabetes mellitus to avoid MetS development.
银屑病、类风湿关节炎和炎症性肠病等慢性炎症性疾病已被报道与代谢综合征（MetS）的发展有关，代谢综合征的特征是中心性肥胖、甘油三酯（TG）升高、高密度脂蛋白（HDL）降低、空腹血糖受损（FBG）和高血压。贝切特病（BD）是一种慢性、免疫炎症性疾病，多系统受累。
本研究旨在探讨 BD 患者 MetS 的患病率和危险因素。
所有患者均符合国际研究组的 BD 标准。根据国家胆固醇教育计划成人治疗专家组 III（NCEP ATP III）标准诊断 MetS。测量和分析平均腰围、体重指数（BMI）、FBG、红细胞沉降率（ESR）、C 反应蛋白（CRP）、总胆固醇、HDL、极低密度脂蛋白（VLDL）、低密度脂蛋白（LDL）、TG、收缩压和舒张压。
共纳入 86 例患者和 72 例健康对照者。患者中有 35.4%存在 MetS，对照组中有 20%存在 MetS（p=0.04）。BD 患者发生 MetS 的风险是健康对照者的 2.67 倍（p<0.05）。多因素分析显示，BD、年龄和 BMI 是发生 MetS 的显著危险因素。疾病的发病年龄、病程、BMI、胃肠道系统受累和神经系统受累与 MetS 风险增加相关（p<0.05）。MetS 随着年龄和病程的增加而增加，且 40 岁以下女性的发生率高于同年龄组健康对照者。
所有 BD 患者均应密切监测高血压、高血脂和糖尿病，以避免 MetS 的发生。
