伴有ATP1A2突变的家族性偏瘫性偏头痛中的急性脑病
Acute encephalopathy in familial hemiplegic migraine with ATP1A2 mutation.
作者信息
Merwick Aine, Fernandez Desiree, McNamara Brian, Harrington Hugh
机构信息
Neurology Department, National Hospital for Neurology and Neurosurgery, London, UK.
出版信息
BMJ Case Rep. 2013 Jun 10;2013:bcr2013009750. doi: 10.1136/bcr-2013-009750.
Abstract
Familial hemiplegic migraine is a rare subtype of migraine with aura which includes motor weakness. A 32-year-old woman with known familial hemiplegic migraine (point mutation in Exon 22 of the ATP1A2 gene) presented with an acute confusional state, after an initially typical migraine. On examination, she had fever (38°C), agitated, with a right hemiparesis and dysphasia. Electroencephalography showed slowing of α rhythm and continuous rhythmical δ activity in the left hemisphere. She recovered 48 h after the onset of encephalopathic episode. Electroencephalography after recovery showed resolution of the abnormal slowing of the α waveforms.
摘要
家族性偏瘫性偏头痛是偏头痛伴先兆的一种罕见亚型，其中包括运动无力。一名32岁已知患有家族性偏瘫性偏头痛（ATP1A2基因第22外显子点突变）的女性，在最初出现典型偏头痛后，出现了急性意识模糊状态。检查发现，她发热（38°C），烦躁不安，有右侧偏瘫和言语困难。脑电图显示左半球α节律减慢和持续性节律性δ活动。脑病发作48小时后她康复了。康复后的脑电图显示α波异常减慢消失。
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