Brenner M, Mukai D S, Russell J E, Spiritus E M, Wilson A F
Pulmonary and Critical Care Division, University of California Irvine Medical Center, Orange.
Chest. 1990 Aug;98(2):421-7. doi: 10.1378/chest.98.2.421.
Airway occlusion pressure correlates with central respiratory drive. The airway occlusion pressure (P0.1) may be an excellent predictor of the ability of patients with obstructive lung disease to wean from mechanical ventilation. We describe a new method for measuring P0.1 using digitized signals generated from standard respiratory equipment and a computer program to automatically determine P0.1 values. The accuracy of this new method was tested by comparison with standard analog recorder methods using a mechanical lung model, in ventilated patients in an intensive care unit, and in normal volunteers. In all settings, excellent correlation was obtained between P0.1 measurements by the digital Servo and standard analog methods (r = 0.99). This new method permits accurate and automatic determination of P0.1 in ventilated patients using standard respiratory equipment. The rapid response and ease of use of this method should enable evaluation of a number of physiologic variables involved in respiratory control in ventilated and nonventilated patients.
气道闭塞压与中枢呼吸驱动相关。气道闭塞压（P0.1）可能是阻塞性肺疾病患者机械通气撤机能力的一个极佳预测指标。我们描述了一种使用标准呼吸设备产生的数字化信号和计算机程序自动确定P0.1值来测量P0.1的新方法。通过使用机械肺模型、重症监护病房中接受机械通气的患者以及正常志愿者，将这种新方法与标准模拟记录器方法进行比较，测试了该新方法的准确性。在所有情况下，数字伺服法和标准模拟法测得的P0.1之间均具有良好的相关性（r = 0.99）。这种新方法允许使用标准呼吸设备准确、自动地测定接受机械通气患者的P0.1。该方法的快速响应和易用性应能使人们评估通气和未通气患者呼吸控制中涉及的许多生理变量。
