Kuo C D, Lee J D, Wang J H
Department of Respiratory Therapy, Veterans General Hospital, Taipei, Taiwan, Republic of China.
Chin J Physiol. 1990;33(1):63-71.
Multiple organ failure (MOF) associated with adult respiratory distress syndrome (ARDS) secondary to sepsis, trauma, etc., continues to be a syndrome with poor prognosis. It is generally accepted that tissue hypoxia is associated with the subsequent development of MOF. The purpose of this study was to find the relationship between the reduced tissue oxygen extraction and the severity of the syndrome. By correlating either the tissue oxygen extraction per unit volume of blood, CaO2-CvO2, or the oxygen extraction ratio, (CaO2-CvO2)/CaO2, with the intrapulmonary shunt, Qs/Qt, we found that there were significant inverse correlations between these two parameters of tissue oxygen extraction and the severity of the illness in patients with ARDS and MOF. The observed reduction in tissue extraction of oxygen may be related to the development of deranged metabolism in ARDS and MOF.
与脓毒症、创伤等继发的成人呼吸窘迫综合征（ARDS）相关的多器官功能衰竭（MOF）仍然是一种预后不良的综合征。人们普遍认为组织缺氧与MOF随后的发展有关。本研究的目的是找出组织氧摄取减少与该综合征严重程度之间的关系。通过将每单位体积血液的组织氧摄取量（CaO2-CvO2）或氧摄取率（CaO2-CvO2）/CaO2与肺内分流（Qs/Qt）相关联，我们发现这两个组织氧摄取参数与ARDS和MOF患者的疾病严重程度之间存在显著的负相关。观察到的组织氧摄取减少可能与ARDS和MOF中代谢紊乱的发展有关。
