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未折叠蛋白反应在抗肿瘤免疫中的双面作用。

A Janus-faced role of the unfolded protein response in antitumor immunity.

作者信息

Mahadevan Navin R, Rodvold Jeffrey J, Zanetti Maurizio

机构信息

The Laboratory of Immunology; Department of Medicine and Moores Cancer Center; University of California; San Diego, CA USA.

出版信息

Oncoimmunology. 2013 May 1;2(5):e23901. doi: 10.4161/onci.23901.

DOI:10.4161/onci.23901
PMID:23762789
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3667895/
Abstract

The unfolded protein response (UPR) has been established as a cell-intrinsic mechanism of survival for malignant cells facing microenvironmental stressors. Recent evidence indicates that the UPR also modulates antitumor immunity. Here, we discuss the bi-faced role of the UPR as it both promotes and antagonizes antitumor T-cell immunity.

摘要

未折叠蛋白反应（UPR）已被确立为恶性细胞面对微环境应激源时的一种细胞内在生存机制。最近的证据表明，UPR 还能调节抗肿瘤免疫。在此，我们讨论 UPR 的双面作用，因为它既能促进又能拮抗抗肿瘤 T 细胞免疫。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e7c/3667895/ed526cb229db/onci-2-e23901-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e7c/3667895/ed526cb229db/onci-2-e23901-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e7c/3667895/ed526cb229db/onci-2-e23901-g1.jpg

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Cell-extrinsic effects of tumor ER stress imprint myeloid dendritic cells and impair CD8⁺ T cell priming.肿瘤内质网应激的细胞外效应可影响髓系树突状细胞，并损害 CD8⁺ T 细胞的激活。
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8
The unfolded protein response (UPR)-activated transcription factor X-box-binding protein 1 (XBP1) induces microRNA-346 expression that targets the human antigen peptide transporter 1 (TAP1) mRNA and governs immune regulatory genes.未折叠蛋白反应（UPR）激活转录因子 X 盒结合蛋白 1（XBP1）诱导 microRNA-346 的表达，该 microRNA-346 靶向人类抗原肽转运体 1（TAP1）mRNA，并调控免疫调节基因。
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