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骨桥蛋白，一种可能的癌症干细胞及其恶性微环境调节因子。

Osteopontin, a possible modulator of cancer stem cells and their malignant niche.

作者信息

Rao Guanhua, Du Lei, Chen Quan

机构信息

College of Life Sciences; Nankai University; Tianjin, China.

出版信息

Oncoimmunology. 2013 May 1;2(5):e24169. doi: 10.4161/onci.24169.

DOI:10.4161/onci.24169
PMID:23762797
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3667903/
Abstract

The reciprocal interaction between cancer stem cells and their niche is important for oncogenesis and tumor progression, but the factors involved in this interrelationship remain largely unknown. We have recently demonstrated that osteopontin plays a crucial role in the crosstalk between CD44 colorectal cancer stem cells and tumor-associated macrophages.

摘要

癌症干细胞与其微环境之间的相互作用对肿瘤发生和肿瘤进展至关重要，但这种相互关系中涉及的因素仍大多未知。我们最近证明，骨桥蛋白在CD44结直肠癌干细胞与肿瘤相关巨噬细胞之间的相互作用中起关键作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f1c/3667903/e46cb1d41298/onci-2-e24169-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f1c/3667903/e46cb1d41298/onci-2-e24169-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f1c/3667903/e46cb1d41298/onci-2-e24169-g1.jpg

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