Ruffatti A, Rossi L, Calligaro A, Del Ross T, Lagni M, Marson P, Todesco S
Division of Rheumatology, University of Padova, Italy.
Gerontology. 1990;36(2):104-11. doi: 10.1159/000213183.
Antinuclear antibodies, anticardiolipin antibodies and IgM rheumatoid factor were determined in 300 healthy aged subjects, comparing their prevalence to that in 100 healthy subjects aged between 19 and 44 years and 352 patients under 65 years of age, affected by various systemic rheumatic diseases. Increased production of IgM rheumatoid factor and antinuclear and anticardiolipin antibodies was found as characteristic of aged humans, and suggested that a correction for age should be considered in evaluating the clinical significance of autoantibody profiles in elderly patients.
对300名健康老年人测定了抗核抗体、抗心磷脂抗体和IgM类风湿因子，并将其患病率与100名年龄在19至44岁之间的健康受试者以及352名65岁以下患有各种系统性风湿疾病的患者进行比较。发现IgM类风湿因子以及抗核抗体和抗心磷脂抗体产生增加是老年人的特征，这表明在评估老年患者自身抗体谱的临床意义时应考虑年龄校正。
