Department of Gynecology and Obstetric, Hvidovre University Hospital, Hvidovre, Denmark.
Acta Obstet Gynecol Scand. 2013 Sep;92(9):1023-31. doi: 10.1111/aogs.12197. Epub 2013 Jul 23.
Human papillomavirus (HPV) genotype distribution in invasive cervical cancers may differ by geographic region. The primary objective of this study was to estimate HPV-genotype distribution in Danish women with a diagnosis of invasive cervical cancer.
Observational, cross-sectional.
Danish data from a multi-center study undertaken in 12 European countries.
A total of 342 archived fixed tissue samples with diagnosis of invasive cervical cancer from the Departments of Pathology in the University Hospitals in Hvidovre and Odense, Denmark, were anonymized and shipped to a central laboratory for histopathology review and PCR testing for HPV DNA. A standardized HPV-test methodology was used to enable comparison of HPV-type distribution.
Occurrence of HPV genotypes in Danish women with cervical cancer.
There were 261 samples evaluated as histologically adequate and 251 (96%) of these were HPV-positive (HPV+). The most frequent diagnosis was squamous cell carcinoma (78.9% of histological adequate and 79.3% of HPV+). Adenocarcinoma, adenosquamous carcinoma and other types were found in 14.9, 3.4 and 2.7% of the histologically adequate group and 14.7, 3.6 and 2.4% of the HPV+ group, respectively. In 92.8% of HPV+ women only a single HPV type was diagnosed. HPV-type distribution in the latter population was as follows: HPV-16: 62.2%; HPV-18: 14.6%; HPV-33: 6.9%; HPV-45: 6.4% and HPV-31: 3.4%. Of the HPV+ women, 6.4% were diagnosed with multiple HPV types and 0.8% had unknown HPV types.
HPV-16 and -18 are detected in 74.3% of Danish women with diagnosis of invasive cervical cancer, while HPV-16, -18, -31, -33, -45 and 58 are detected in 90.0% of women with invasive cervical disease.
人乳头瘤病毒（HPV）基因型在浸润性宫颈癌中的分布可能因地理位置而异。本研究的主要目的是估计丹麦浸润性宫颈癌女性的 HPV 基因型分布。
观察性、横断面研究。
来自丹麦的多中心研究的数据，该研究在 12 个欧洲国家进行。
从丹麦 Hvidovre 和 Odense 大学医院的病理学系收集了 342 份存档的固定组织样本，这些样本均为浸润性宫颈癌诊断，经过匿名处理并运往一个中央实验室进行组织病理学复查和 HPV DNA 的 PCR 检测。采用标准化的 HPV 检测方法，以比较 HPV 型别的分布。
丹麦宫颈癌女性 HPV 基因型的发生率。
共有 261 例样本进行了组织学评估，其中 251 例（96%）为 HPV 阳性（HPV+）。最常见的诊断是鳞状细胞癌（组织学评估充分的为 78.9%，HPV+的为 79.3%）。腺癌、腺鳞癌和其他类型分别占组织学评估充分组的 14.9%、3.4%和 2.7%，HPV+组的 14.7%、3.6%和 2.4%。在 92.8%的 HPV+女性中，仅诊断出一种 HPV 型别。后者人群中的 HPV 型别分布如下：HPV-16：62.2%；HPV-18：14.6%；HPV-33：6.9%；HPV-45：6.4%；HPV-31：3.4%。HPV+女性中，6.4%被诊断为多种 HPV 型别，0.8%为未知 HPV 型别。
在丹麦诊断为浸润性宫颈癌的女性中，检测到 HPV-16 和 -18 占 74.3%，而在浸润性宫颈癌患者中，HPV-16、-18、-31、-33、-45 和 58 占 90.0%。
