Department of Otolaryngology - Head and Neck Surgery, The University of Toronto, Toronto, ON M5G 2N2, Canada.
Syst Rev. 2013 Jun 13;2:40. doi: 10.1186/2046-4053-2-40.
Botulinum toxin A is a commonly used biological medication in the field of facial plastic surgery. Currently, there are three distinct formulations of botulinum toxin A, each with their purported benefits and advantages. However, there is considerable confusion as to the relative efficacy and side-effects associated with each formulation. Therefore, the purpose of this paper is to systematically assess published studies and perform a meta-analysis to determine if there is a significant advantage of any of the individual formulations.
METHODS/DESIGN: A systematic literature search was performed for all relevant English language randomized controlled trials using Embase, Cumulative Index to Nursing and Allied Health Literature (CINAHL), MEDLINE, World Health Organization (WHO) International Clinical Trials Registry Platform, European Union (EU) Clinical Trials Register, Cochrane Library databases of clinical trials, and ClinicalTrials.gov. Inclusion criteria included any randomized controlled trial (RCT) that assessed the use of botulinum toxin for cosmetic purposes. The included articles were also analyzed for bias using the Cochrane Collaboration's tool for assessing the risk of bias in RCTs.
The results of this review will provide clinicians with an unbiased, high level of evidence of the comparative efficacy of individual preparations of botulinum toxin A.
肉毒毒素 A 是整形外科学领域常用的生物药物。目前，有三种不同的肉毒毒素 A 制剂，每种制剂都有其声称的益处和优势。然而，对于每种制剂的相对疗效和副作用存在相当大的混淆。因此，本文的目的是系统评估已发表的研究并进行荟萃分析，以确定是否存在任何单一制剂的显著优势。
方法/设计：使用 Embase、 Cumulative Index to Nursing and Allied Health Literature (CINAHL)、MEDLINE、世界卫生组织 (WHO) 国际临床试验注册平台、欧盟 (EU) 临床试验注册处、 Cochrane 图书馆临床试验数据库和 ClinicalTrials.gov 对所有相关的英语随机对照试验进行系统文献检索。纳入标准包括评估肉毒毒素用于美容目的的任何随机对照试验 (RCT)。还使用 Cochrane 协作组评估 RCT 偏倚的工具对纳入的文章进行偏倚分析。
本综述的结果将为临床医生提供关于肉毒毒素 A 各制剂比较疗效的无偏、高水平证据。
