培养异体角质形成细胞用于大面积烧伤：一项长达15年的回顾性研究

Cultured allogenic keratinocytes for extensive burns: a retrospective study over 15 years.

作者信息

Auxenfans Celine, Shipkov Hristo, Bach Christine, Catherine Zulma, Lacroix Pierre, Bertin-Maghit Marc, Damour Odile, Braye Fabienne

机构信息

Bank of Skin Substitutes, Edouard Herriot Hospital, Lyon, France; Department of Burns and Plastic and Reconstructive Surgery, Edouard Herriot Hospital, Lyon, France.

出版信息

Burns. 2014 Feb;40(1):82-8. doi: 10.1016/j.burns.2013.05.005. Epub 2013 Jun 12.

DOI:10.1016/j.burns.2013.05.005

PMID:23764150

Abstract

UNLABELLED

The aim was to review the use and indications of cultured allogenic keratinocytes (CAlloK) in extensive burns and their efficiency.

MATERIALS AND METHODS

This retrospective study comprised 15 years (1997-2012).

INCLUSION CRITERIA

all patients who received CAlloK.

EXCLUSION CRITERIA

patients who died before complete healing. Evaluation criteria were clinical. Time and success of wound healing after CAlloK use were evaluated.

RESULTS

The CAlloK were used for 2 indications - STSG donor sites and deep 2nd degree burns in extensively burned patients. A total of 70 patients were included with severity Baux score of 99.2 (from 51 to 144) and mean percentage of TBSA of 63.49% (from 21 to 96%). Fifty nine patients received CAlloK for STSG donor sites with a mean number of applications of 4 and mean surface of 3800 cm(2) per patient. Treated donor sites were re-harvested 2.5 times. The mean time of complete epithelialization was 7 days. In 11 patients, CAlloK were used for deep 2nd degree burns. The mean percentage of burned surface was 73.7%. The mean surface of CAlloK per patient was 2545 cm(2). Complete healing was achieved in 6.4 days.

CONCLUSION

The CAlloK allow rapid healing of STSG donor-sites and deep 2nd second degree burns in extensively burned patients.

摘要

未标注

目的是回顾培养的同种异体角质形成细胞（CAlloK）在大面积烧伤中的使用情况、适应证及其有效性。

材料与方法

这项回顾性研究涵盖15年（1997 - 2012年）。

纳入标准

所有接受CAlloK治疗的患者。

排除标准

在完全愈合前死亡的患者。评估标准为临床指标。对使用CAlloK后伤口愈合的时间和成功率进行评估。

结果

CAlloK用于两个适应证——大面积烧伤患者的自体皮片供区和深二度烧伤。共纳入70例患者，Baux评分平均为99.2（范围51至144），总体表面积平均百分比为63.49%（范围21至96%）。59例患者接受CAlloK用于自体皮片供区，每位患者平均应用次数为4次，平均面积为3800平方厘米。处理后的供区可再次取皮2.5次。完全上皮化的平均时间为7天。11例患者使用CAlloK治疗深二度烧伤。烧伤面积平均百分比为73.7%。每位患者CAlloK的平均面积为2545平方厘米。6.4天实现完全愈合。