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一线治疗导致混合感染中未被发现的耐多药结核病扩增。

Undetected multidrug-resistant tuberculosis amplified by first-line therapy in mixed infection.

机构信息

Imperial College London, London, UK.

出版信息

Emerg Infect Dis. 2013 Jul;19(7):1138-41. doi: 10.3201/1907.130313.

DOI:10.3201/1907.130313
PMID:23764343
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3713993/
Abstract

Infections with >1 Mycobacterium tuberculosis strain(s) are underrecognized. We show, in vitro and in vivo, how first-line treatment conferred a competitive growth advantage to amplify a multidrug-resistant M. tuberculosis strain in a patient with mixed infection. Diagnostic techniques that identify mixed tubercle bacilli populations are needed to curb the spread of multidrug resistance.

摘要

感染 >1 株结核分枝杆菌的情况未被充分认识。我们通过体外和体内实验表明，一线治疗如何赋予一种耐多药结核分枝杆菌菌株竞争生长优势，从而在混合感染患者中扩增该菌株。需要采用能够鉴定混合结核分枝杆菌种群的诊断技术来遏制耐多药的传播。

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