沙特阿拉伯结核分枝杆菌对抗结核药物的耐药性不断增加。
Increasing resistance of M. tuberculosis to anti-TB drugs in Saudi Arabia.
作者信息
Khan M Y, Kinsara A J, Osoba A O, Wali S, Samman Y, Memish Z
机构信息
King Khalid National Guard Hospital, Jeddah, Saudi Arabia.
出版信息
Int J Antimicrob Agents. 2001 May;17(5):415-8. doi: 10.1016/s0924-8579(01)00298-9.
The incidence of drug resistance in Mycobacterium tuberculosis (MTB) isolated from our hospital between April 1996 and March 1998 was compared with an earlier study (1993-1995). Thirty (29.7%) of 101 MTB isolates were resistant to one or more anti-TB drugs and 21 (20%) of 101 were multi-drug resistant M. tuberculosis (MDR-TB). Resistance was most common to isoniazid (28.7%), followed by streptomycin (22.8%) and rifampicin (20.8%). Resistance to pyrazinamide and ethambutol was 7.9 and 6.9%, respectively. There was a three-fold increase in resistance compared with the earlier study.
将1996年4月至1998年3月期间从我院分离出的结核分枝杆菌（MTB）的耐药发生率与一项早期研究（1993 - 1995年）进行了比较。101株MTB分离株中有30株（29.7%）对一种或多种抗结核药物耐药，101株中有21株（20%）为耐多药结核分枝杆菌（MDR - TB）。对异烟肼的耐药最为常见（28.7%），其次是链霉素（22.8%）和利福平（20.8%）。对吡嗪酰胺和乙胺丁醇的耐药率分别为7.9%和6.9%。与早期研究相比，耐药率增加了两倍。
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