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PLoS One. 2017 May 18;12(5):e0176522. doi: 10.1371/journal.pone.0176522. eCollection 2017.
2
Transmission of Extensively Drug-Resistant Tuberculosis in South Africa.南非广泛耐药结核病的传播
N Engl J Med. 2017 Jan 19;376(3):243-253. doi: 10.1056/NEJMoa1604544.
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Removing the bottleneck in whole genome sequencing of Mycobacterium tuberculosis for rapid drug resistance analysis: a call to action.消除结核分枝杆菌全基因组测序中的瓶颈以进行快速耐药性分析：行动呼吁
Int J Infect Dis. 2017 Mar;56:130-135. doi: 10.1016/j.ijid.2016.11.422. Epub 2016 Dec 13.
4
Concordance between molecular and phenotypic testing of Mycobacterium tuberculosis complex isolates for resistance to rifampin and isoniazid in the United States.美国结核分枝杆菌复合群分离株对利福平和异烟肼耐药性的分子检测与表型检测的一致性
J Clin Microbiol. 2014 Jun;52(6):1932-7. doi: 10.1128/JCM.00417-14. Epub 2014 Mar 19.
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Undetected multidrug-resistant tuberculosis amplified by first-line therapy in mixed infection.一线治疗导致混合感染中未被发现的耐多药结核病扩增。
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Molecular detection of mutations associated with first- and second-line drug resistance compared with conventional drug susceptibility testing of Mycobacterium tuberculosis.与传统结核分枝杆菌药物敏感性试验相比，检测与一线和二线耐药相关的基因突变。
Antimicrob Agents Chemother. 2011 May;55(5):2032-41. doi: 10.1128/AAC.01550-10. Epub 2011 Feb 7.
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The clonal composition of Mycobacterium tuberculosis in clinical specimens could be modified by culture.结核分枝杆菌在临床标本中的克隆组成可能会受到培养的影响。
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Co-infection with pansensitive and multidrug-resistant strains of Mycobacterium tuberculosis.结核分枝杆菌泛敏感菌株与耐多药菌株的合并感染。
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Double infection with a resistant and a multidrug-resistant strain of Mycobacterium tuberculosis.结核分枝杆菌耐药菌株与多重耐药菌株的双重感染。
Emerg Infect Dis. 2000 Sep-Oct;6(5):548-51. doi: 10.3201/eid0605.000518.
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Mixed-strain infection with a drug-sensitive and multidrug-resistant strain of Mycobacterium tuberculosis.结核分枝杆菌药物敏感株与多药耐药株的混合菌株感染。
Lancet. 1995 Jun 10;345(8963):1512. doi: 10.1016/s0140-6736(95)91073-5.

同一患者感染耐多药和药敏结核分枝杆菌。

Drug-Susceptible and Multidrug-Resistant Mycobacterium tuberculosis in a Single Patient.

出版信息

Emerg Infect Dis. 2019 Nov;25(11):2120-2121. doi: 10.3201/eid2511.180638. Epub 2019 Nov 17.

DOI:10.3201/eid2511.180638
PMID:31454310
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6810186/
Abstract

A patient who had initial infection with mixed strains of drug-susceptible and multidrug-resistant tuberculosis was presumed to have acquired drug resistance before confirmation that sequential strains were genotypically distinct. Transmitted infection with mixed strains is likely underappreciated; identifying these infections requires spoligotyping and whole-genome sequencing.

摘要

一位最初感染了耐多药和药物敏感混合株结核分枝杆菌的患者，在确认连续分离株在基因型上存在明显差异之前，被假定已经获得了耐药性。混合株的传播感染可能被低估了；识别这些感染需要 spoligotyping 和全基因组测序。