Emerg Infect Dis. 2019 Nov;25(11):2120-2121. doi: 10.3201/eid2511.180638. Epub 2019 Nov 17.
A patient who had initial infection with mixed strains of drug-susceptible and multidrug-resistant tuberculosis was presumed to have acquired drug resistance before confirmation that sequential strains were genotypically distinct. Transmitted infection with mixed strains is likely underappreciated; identifying these infections requires spoligotyping and whole-genome sequencing.
一位最初感染了耐多药和药物敏感混合株结核分枝杆菌的患者,在确认连续分离株在基因型上存在明显差异之前,被假定已经获得了耐药性。混合株的传播感染可能被低估了;识别这些感染需要 spoligotyping 和全基因组测序。