Laboratory of Neurophysiology and Neuroimaging, Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Goethe University, Frankfurt/Main, Germany.
J Affect Disord. 2013 Sep 5;150(2):430-40. doi: 10.1016/j.jad.2013.04.036. Epub 2013 Jun 12.
Episodic memory deficits affect the majority of patients with bipolar disorder (BD).
The study investigates episodic memory performance through different approaches, including behavioural measures, physiological parameters, and the underlying functional activation patterns with functional neuroimaging (fMRI).
26 Remitted BD patients and a matched group of healthy controls underwent a verbal episodic memory test together with monitored autonomic response, psychopathological ratings and functional magnetic resonance imaging (fMRI) during the verbal episodic memory test.
Compared to healthy controls, BD patients performed significantly worse during the episodic memory task. The results further indicate that verbal episodic memory deficits in BD are associated with abnormal functional activity patterns in frontal, occipital and limbic regions, and an increase in stress parameters.
We aimed to minimise sample heterogeneity by setting clear criteria for remission, based on the scores of a depression (BDI II) and mania scale (BRMAS) and on the DSM IV criteria. However, our patients were not symptom-free and scored higher on BDI II scores than the control group.
The results are of interest for the treatment of cognitive symptoms in BD patients, as persistent cognitive impairment may hamper full rehabilitation.
发作性记忆缺陷影响大多数双相情感障碍（BD）患者。
本研究通过不同方法研究发作性记忆性能，包括行为测量、生理参数和功能神经影像学（fMRI）下的潜在功能激活模式。
26 名缓解期 BD 患者和一组匹配的健康对照者接受了言语发作性记忆测试，同时监测自主反应、精神病理学评分和功能磁共振成像（fMRI）在言语发作性记忆测试期间。
与健康对照组相比，BD 患者在发作性记忆任务中表现明显较差。结果进一步表明，BD 中的言语发作性记忆缺陷与额叶、枕叶和边缘区域的功能活动模式异常以及应激参数增加有关。
我们旨在通过基于抑郁（BDI II）和躁狂量表（BRMAS）以及 DSM IV 标准的分数，为缓解设定明确标准，将样本异质性降至最低。然而，我们的患者并非无症状，BDI II 评分高于对照组。
这些结果对治疗 BD 患者的认知症状很有意义，因为持续的认知障碍可能会阻碍全面康复。
