Young Kymberly D, Bellgowan Patrick S F, Bodurka Jerzy, Drevets Wayne C
Laureate Institute for Brain Research, 6655 South Yale Avenue, Tulsa, OK 74136, USA.
National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.
Brain Sci. 2015 Apr 24;5(2):144-64. doi: 10.3390/brainsci5020144.
Overgeneral autobiographical memory (AM) manifests in individuals with major depressive disorder (MDD) tested during depressed (dMDD) or remitted phases (rMDD), and healthy individuals at high-risk (HR) for developing MDD. The current study aimed to elucidate differences in hemodynamic correlates of AM recall between rMDDs, HRs, and controls (HCs) to identify neural changes following previous depressive episodes without the confound of current depressed mood. HCs, HRs, and unmedicated rMDDs (n = 20/group) underwent fMRI while recalling AMs in response to emotionally valenced cue words. HRs and rMDDs recalled fewer specific and more categorical AMs relative to HCs. During specific AM recall, HRs had increased activity relative to rMDDs and HCs in left ventrolateral prefrontal cortex (VLPFC) and lateral orbitofrontal cortex. During positive specific AM recall, HRs and HCs had increased activity relative to rMDDs in bilateral dorsomedial prefrontal cortex (DMPFC) and left precuneus. During negative specific AM recall HRs and HCs had increased activity in left VLPFC and right DMPFC, while rMDDs had increased activity relative to HRs and HCs in right DLPFC and precuneus. Differential recruitment of medial prefrontal regions implicated in emotional control suggests experiencing a depressive episode may consequently reduce one's ability to regulate emotional responses during AM recall.
过度概括性自传体记忆（AM）在重度抑郁症（MDD）患者处于抑郁期（dMDD）或缓解期（rMDD）时接受测试时会表现出来，在有患MDD高风险（HR）的健康个体中也会出现。本研究旨在阐明rMDD患者、HR个体和对照组（HC）在AM回忆的血流动力学相关性方面的差异，以识别既往抑郁发作后神经的变化，而不受当前抑郁情绪的干扰。HC、HR个体和未服药的rMDD患者（每组n = 20）在根据带有情绪色彩的提示词回忆AM时接受功能磁共振成像（fMRI）检查。与HC相比，HR个体和rMDD患者回忆起的具体AM较少，而分类AM较多。在回忆具体AM期间，相对于rMDD患者和HC，HR个体在左侧腹外侧前额叶皮质（VLPFC）和外侧眶额皮质的活动增加。在回忆积极的具体AM期间，相对于rMDD患者，HR个体和HC在双侧背内侧前额叶皮质（DMPFC）和左侧楔前叶的活动增加。在回忆消极的具体AM期间，HR个体和HC在左侧VLPFC和右侧DMPFC的活动增加，而rMDD患者在右侧背外侧前额叶皮质（DLPFC）和楔前叶的活动相对于HR个体和HC增加。参与情绪控制的内侧前额叶区域的不同激活表明，经历抑郁发作可能会降低个体在AM回忆期间调节情绪反应的能力。
