ICAP, Mailman School of Public Health, Columbia University, New York, NY 10032, USA.
J Acquir Immune Defic Syndr. 2013 Jul;63 Suppl 2:S200-7. doi: 10.1097/QAI.0b013e3182986fc6.
The demonstration of the efficacy of antiretroviral therapy (ART) for HIV prevention in heterosexual HIV serodiscordant couples has resulted in the call for widespread implementation of "Treatment as Prevention" (TasP) to confront the challenge of continued transmission of HIV. In addition, evidence of the possible effect of use of ART on decreasing the incidence of tuberculosis (TB) in persons living with HIV has also contributed further enthusiasm. Mathematical modeling studies evaluating the potential impact of TasP on the trajectory of the HIV and TB epidemics have inspired discussions about a possible future without AIDS. We present the evidence regarding the effect of ART on the incidence of HIV and TB, benefits and risks associated with embracing TasP, and the need for multicomponent prevention strategies and for further research to generate empiric data on the effect of TasP on HIV and TB at a population level.
抗逆转录病毒疗法（ART）在 HIV 血清学异性性伴侣中的预防效果的证明，促使人们呼吁广泛实施“治疗即预防”（TasP）策略，以应对 HIV 持续传播的挑战。此外，ART 可能对降低 HIV 感染者结核病（TB）发病率的证据也进一步激发了人们的热情。评估 TasP 对 HIV 和 TB 流行轨迹的潜在影响的数学建模研究，激发了关于未来可能没有艾滋病的讨论。我们介绍了 ART 对 HIV 和 TB 发病率的影响的证据，以及接受 TasP 所带来的益处和风险，以及需要多方面的预防策略和进一步的研究，以在人群水平上获得关于 TasP 对 HIV 和 TB 的影响的经验数据。
