Velmurugan C, Sundaram T, Sampath Kumar R, Vivek B, Sheshadrishekar D, Ashok Kumar B S
Sri. K.V.College of pharmacy, Department of Pharmacology, Chickaballapur, Karnataka, 562101 India.
Med J Malaysia. 2011 Mar;66(1):22-6.
The hypoglycemic and hypolipidemic effect of Ethanolic extract of Ougeinia oojeinensis (200mg/kg) bark was evaluated with measurements including, Body weight, blood glucose level, urine glucose and biochemical parameters. The ethanolic extracts of the powdered bark was tested for its efficacy in alloxan-induced diabetic rats. Animals were induced for diabetes with Alloxan (150 mg/kg of body weight- i.p.) and treated orally with Ethanolic extract of Ougeinia oojeinensis. The extracts were also evaluated for acute oral toxicity studies and its effect on different biochemical parameters. The extracts showed significant (p<0.01) antihyperglycemic and hypolipidemic activity as compared to diabetic control. The extract shows beneficial effects on blood glucose and urine glucose level. It also reduces the elevated biochemical parameters such as triglycerides (TGL), low density lipoprotein (LDL), very low density lipoprotein (VLDL), Total Cholesterol (TC) and increased the reduced level of high density lipoprotein (HDL) and body weight, which might be due to presence of steroids, tannins, alkaloids and triterpenoids present in that extract. Thus ethanolic extract could serve as good oral hypoglycemic agents and seems to be promising for the development of phytomedicines for diabetes mellitus.
对奥吉尼亚苏木树皮乙醇提取物（200毫克/千克）的降血糖和降血脂作用进行了评估，测量指标包括体重、血糖水平、尿糖和生化参数。对该树皮粉末的乙醇提取物在四氧嘧啶诱导的糖尿病大鼠中的功效进行了测试。用四氧嘧啶（150毫克/千克体重，腹腔注射）诱导动物患糖尿病，并用奥吉尼亚苏木树皮乙醇提取物进行口服治疗。还对提取物进行了急性口服毒性研究及其对不同生化参数的影响评估。与糖尿病对照组相比，提取物显示出显著（p<0.01）的抗高血糖和降血脂活性。该提取物对血糖和尿糖水平有有益影响。它还降低了甘油三酯（TGL）、低密度脂蛋白（LDL）、极低密度脂蛋白（VLDL）、总胆固醇（TC）等升高的生化参数，并提高了高密度脂蛋白（HDL）降低的水平和体重，这可能是由于该提取物中存在类固醇、单宁、生物碱和三萜类化合物。因此，乙醇提取物可作为良好的口服降糖剂，似乎有望用于开发治疗糖尿病的植物药。
