Automation of dihydroxyaluminum sodium carbonate analysis in antacid tablets by energy dispersive X-ray fluorescence.

A sensitive, specific, automated energy dispersive X-ray fluorescence (EDXRF) method for determination of anhydrous dihydroxyaluminum sodium carbonate in antacid tablets has been developed. The compound was quantitated by impact grinding, pelletizing at 10 tons pressure, and monitoring the aluminum by using a rhodium anode X-ray tube, high resolution thermoelectrically cooled Si(Li) detector with sample spinning, and computer data processing. The assay procedure was validated with spiked laboratory-prepared samples at 100 +/- 20% levels. The average recovery was 100.6% with a relative standard deviation of 1.6% (n = 14). Instrument precision was determined and found to have an average relative standard deviation of 1.0% (n = 16). In addition, analysis precision by the EDXRF method was compared to that for titration and autoanalyzer methodologies and found to be statistically comparable. The sample precision had an averaged relative standard deviation of 2.7% (n = 16) by X-ray methodology. The advantages of this EDXRF method include increased sample throughout with excellent precision and accuracy, no solvent usage, and automated data handling.