Chin K-Y, Ima-Nirwana S, Mohamed I N, Aminuddin A, Ngah W Z W
Pharmacology Department, Faculty of Medicine, Universiti Kebangsaan Malaysia.
Exp Clin Endocrinol Diabetes. 2013 Jul;121(7):407-12. doi: 10.1055/s-0033-1345164. Epub 2013 Jun 13.
Testosterone and sex hormone-binding globulin (SHBG) have been shown to be associated with metabolic syndrome (MS) in men. This study aimed at validating these relationships in a group of middle-aged and elderly men and assessing their strength of association to MS. A cross-sectional study of 332 Malaysian men aged 40 years and above was conducted. The blood of subject was collected under fasting condition for determination of testosterone, SHBG, glucose and lipid levels. Their medical history, smoking and alcohol consumption status, waist circumference (WC), body mass index (BMI) and blood pressure (BP) were recorded. All testosterone and SHBG levels were significantly reduced in MS subjects compared to non-MS subjects (p<0.05). Testosterone and SHBG were correlated significantly with most of the MS indicators without adjustments. In multiple regression analysis, the triglyceride level was the only MS indicator that was significantly, inversely and independently associated with all testosterone measurements and SHBG (p<0.05). Waist circumference was significantly and negatively associated with SHBG level (p<0.05) though not independent of BMI. Total testosterone and SHBG were significantly and inversely associated with the presence of MS. Testosterone and SHBG are potential intervention targets for the prevention of MS in men.
睾酮和性激素结合球蛋白（SHBG）已被证明与男性代谢综合征（MS）有关。本研究旨在验证一组中老年男性中的这些关系，并评估它们与MS的关联强度。对332名40岁及以上的马来西亚男性进行了一项横断面研究。在空腹条件下采集受试者的血液，以测定睾酮、SHBG、血糖和血脂水平。记录他们的病史、吸烟和饮酒状况、腰围（WC）、体重指数（BMI）和血压（BP）。与非MS受试者相比，MS受试者的所有睾酮和SHBG水平均显著降低（p<0.05）。在未进行调整的情况下，睾酮和SHBG与大多数MS指标显著相关。在多元回归分析中，甘油三酯水平是唯一与所有睾酮测量值和SHBG显著、呈负相关且独立相关的MS指标（p<0.05）。腰围与SHBG水平显著负相关（p<0.05），尽管并非独立于BMI。总睾酮和SHBG与MS的存在显著负相关。睾酮和SHBG是预防男性MS的潜在干预靶点。
