Zhang Guofeng, Zeng Yu, Liu Zhongyan, Wei Weiwei
Department of General Surgery, Tongji Hospital, Tongji University School of Medicine, Shanghai, 200065, China,
Tumour Biol. 2013 Oct;34(5):2753-7. doi: 10.1007/s13277-013-0830-z. Epub 2013 Jun 14.
Many studies were published to evaluate the association between Nijmegen breakage syndrome 1 (NBS1) 657del5 polymorphism and breast cancer risk, but the results remained inconsistent. To derive a more precise estimation on the possible association, we performed a meta-analysis of previous published studies. Case-control studies on the association between NBS1 657del5 polymorphisms and breast cancer risk were included into this meta-analysis. We used the odds ratio (OR) with 95 % confidence interval (95 % CI) to assess the strength of the association. Ten studies with a total of 25,365 subjects were identified and included into this meta-analysis. Meta-analysis of those ten studies showed that there was a significant association between NBS1 657del5 polymorphisms and breast cancer risk (pooled OR = 2.66, 95 % CI 1.82-3.90, P < 0.001). The cumulative meta-analyses showed a trend of a more significant association between NBS1 657del5 polymorphisms and breast cancer risk as data accumulated by publication year. Thus, our meta-analysis suggests that there was a significant association between NBS1 657del5 polymorphisms and breast cancer risk, and NBS1 657del5 polymorphism results in an increased risk of breast cancer.
许多研究已发表，旨在评估尼美根断裂综合征1（NBS1）657del5多态性与乳腺癌风险之间的关联，但结果仍不一致。为了对可能的关联进行更精确的估计，我们对先前发表的研究进行了荟萃分析。关于NBS1 657del5多态性与乳腺癌风险之间关联的病例对照研究被纳入本荟萃分析。我们使用比值比（OR）及95%置信区间（95%CI）来评估关联强度。共识别出10项研究，涉及25365名受试者，并将其纳入本荟萃分析。对这10项研究的荟萃分析表明，NBS1 657del5多态性与乳腺癌风险之间存在显著关联（合并OR = 2.66，95%CI 1.82 - 3.90，P < 0.001）。累积荟萃分析显示，随着按发表年份积累的数据增多，NBS1 657del5多态性与乳腺癌风险之间的关联有更显著的趋势。因此，我们的荟萃分析表明，NBS1 657del5多态性与乳腺癌风险之间存在显著关联，且NBS1 657del5多态性会导致乳腺癌风险增加。
