Straube W L, Myerson R J, Emami B, Leybovich L B
Radiation Oncology Center, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri 63110.
Int J Hyperthermia. 1990 May-Jun;6(3):665-70. doi: 10.3109/02656739009140962.
Analysis of the results from recent clinical trials has shown that tumour size is a significant prognostic factor in eventual tumour control in patients treated with thermoradiotherapy. The critical issue appears to be the adequate coverage of hyperthermia target volume with 'therapeutic temperature'. Therefore one must choose appropriate applicators for the treatment of a given tumour. Accurate knowledge of performance characteristics of the applicators used in clinics thus becomes crucial. In an attempt to take the first step for the appropriate selection of applicators in clinics several commonly used applicators were evaluated according to their 75%, 50%, and 25% two-dimensional SAR (specific absorption rate) contours at depths of 1-3 cm. The data were subsequently approximated by rectangles. This type of information, even with its limitations, is extremely important in implementing quality assurance in hyperthermia. In this communication we will present such information, and the implications in current hyperthermia clinical trials will be discussed.
近期临床试验结果分析表明，肿瘤大小是热放疗患者最终肿瘤控制的一个重要预后因素。关键问题似乎在于用“治疗温度”充分覆盖热疗靶区。因此，必须为特定肿瘤的治疗选择合适的施源器。准确了解临床所用施源器的性能特征就变得至关重要。为了在临床上迈出正确选择施源器的第一步，根据几种常用施源器在1 - 3厘米深度处的75%、50%和25%二维比吸收率（SAR）轮廓对其进行了评估。随后将数据近似为矩形。这类信息即便有其局限性，但在热疗质量保证实施中极其重要。在本交流中，我们将呈现此类信息，并讨论其对当前热疗临床试验的影响。
