Department of Chemistry, University of Rajasthan, Jaipur, India.
Ultrason Sonochem. 2011 Sep;18(5):1113-7. doi: 10.1016/j.ultsonch.2010.12.010. Epub 2011 Jan 4.
An alternative and environmentally benign pathway for diastereoslective synthesis of fluorinated spiro[indole-3,2'-oxirane]-3'-benzoyl-2(1H)-ones (2a-g) is reported. The spiro[indole-3,2'-oxiranes] derivatives were obtained in 90-97% yield exclusively via the epoxidation of 3-aroylmethylene indole-2-ones with 30% aqueous hydrogen peroxide using cetyltrimethyl ammonium bromide as a phase transfer catalyst under ultrasound irradiation. The lead compounds have been tested for their antimicrobial activity and antioxidant properties.
本文报道了一种对映选择性合成氟代螺[吲哚-3,2'-氧杂环丁烷]-3'-苯甲酰-2(1H)-酮（2a-g）的替代方法，该方法环境友好。螺[吲哚-3,2'-氧杂环丁烷]衍生物是通过在超声辐射下，用十六烷基三甲基溴化铵作为相转移催化剂，用 30%的过氧化氢水溶液氧化 3-芳亚甲基吲哚-2-酮，以 90-97%的收率得到的。对这些先导化合物进行了抗菌活性和抗氧化活性测试。
